Panadol Extra (Paracetamol, Caffeine)

Paracetamol, the active ingredient in Panadol Extra, is an analgesic and antipyretic presented as a tablet for oral use. It relieves mild to moderate pain and reduces fever in adults and children when combined with caffeine for enhanced effect.

GNH USA supplies Panadol Extra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Panadol Extra combines paracetamol and caffeine and acts on pain‑related pathways and central fatigue mechanisms. - Headache: provides rapid relief of tension‑type and migraine‑associated pain. - Fever: lowers elevated body temperature in acute febrile episodes. - Muscular pain: eases soreness and discomfort from minor muscle strains. - Dental pain: reduces pain following dental procedures or toothache. - Menstrual discomfort: lessens cramping and associated headache symptoms.

Adverse reactions to Panadol Extra are generally mild and dose‑dependent.

Common Side Effects: - Nausea: mild stomach upset that may occur after ingestion. - Headache: paradoxical headache in a small proportion of users. - Insomnia: difficulty falling or staying asleep, especially if taken later in the day. - Gastrointestinal discomfort: mild abdominal pain or dyspepsia. - Restlessness: feeling of increased nervous energy.

Serious or Rare Side Effects: - Allergic reaction: rash, itching, swelling, or difficulty breathing. - Hepatotoxicity: liver injury from excessive paracetamol exposure. - Anaphylaxis: severe, life‑threatening allergic response. - Blood‑pressure elevation: significant rise in blood pressure in susceptible individuals. - Cardiac arrhythmia: irregular heart rhythm linked to high caffeine intake.

When using Panadol Extra, consider the following safety measures: - Maximum daily dose: do not exceed the total paracetamol amount recommended for adults. - Liver health: avoid use if you have known hepatic impairment or chronic liver disease. - Caffeine sensitivity: persons prone to insomnia, anxiety, or tachycardia should use cautiously. - Concomitant medications: review all other products containing paracetamol or stimulants. - Pregnancy and breastfeeding: consult a healthcare professional before use. - Store at ambient temperature: keep below 25°C, retain in original packaging, and protect from moisture.

Panadol Extra may interact with several medicines; monitoring is advised.

Major Interactions (Avoid): - Warfarin: increased risk of bleeding due to altered metabolism. - Isoniazid: heightened potential for liver toxicity. - Highly active antiretroviral therapy (HAART): may affect paracetamol clearance.

Moderate Interactions (Monitor Closely): - Selective serotonin reuptake inhibitors (SSRIs): possible increase in bleeding risk. - Diuretics: caffeine may enhance diuretic effect and electrolyte loss. - Anticonvulsants (e.g., carbamazepine): may reduce analgesic efficacy of paracetamol.