Panadol Extend (Paracetamol)

Paracetamol, the active ingredient in Panadol Extend, is an analgesic presented as a tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children.

GNH USA supplies Panadol Extend as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Panadol Extend contains paracetamol, an analgesic that acts on the body's pain‑relief pathways. - Headache: provides relief from tension‑type and mild migraine headaches. - Fever: helps lower elevated body temperature associated with infections. - Musculoskeletal pain: eases aches from back strain, sprains and minor joint discomfort. - Dental pain: reduces discomfort following dental procedures or toothache. - Menstrual cramps: alleviates mild to moderate dysmenorrhoeic pain.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild stomach upset may be experienced. - Rash: occasional skin redness or mild itching. - Elevated liver enzymes: transient increase detected in blood tests.

Serious or Rare Side Effects: - Hepatotoxicity: risk of liver injury with excessive dosing. - Stevens‑Johnson syndrome: severe skin reaction requiring urgent care. - Anaphylaxis: rare allergic response with difficulty breathing. - Blood disorders: uncommon cases of thrombocytopenia or neutropenia.

When using Panadol Extend, consider the following safety measures: - Dose limits: adhere to maximum daily paracetamol intake to avoid liver damage. - Alcohol use: limit alcohol consumption as it may increase hepatic risk. - Liver disease: use with caution in patients with existing liver impairment. - Pregnancy and breastfeeding: consult healthcare professional before use. - Children: ensure appropriate formulation and dosing for pediatric patients. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Paracetamol may interact with several medicines; monitoring is advised.

Major Interactions (Avoid): - Warfarin: may enhance anticoagulant effect and increase bleeding risk. - Isoniazid: can raise risk of liver toxicity when combined.

Moderate Interactions (Monitor Closely): - Antiepileptics (e.g., carbamazepine, phenytoin): may reduce paracetamol plasma levels. - Rifampicin: may increase metabolism of paracetamol, lowering efficacy. - Oral contraceptives: may slightly increase hepatotoxic potential. - HIV protease inhibitors: may alter paracetamol clearance.