Europe — EMA
Panadeine Extra Strength (Paracetamol, Codeine Phosphate Hemihydrate)
GNH USA supplies Panadeine Extra Strength (Paracetamol/Codeine), a combined analgesic for pain and fever. Request a quote for global supply.
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What is Paracetamol, Codeine Phosphate Hemihydrate?
Paracetamol, the active ingredient in Panadeine Extra Strength, is an analgesic and antipyretic presented as a combination tablet for oral use. It treats mild to moderate pain and reduces fever in adults. GNH USA supplies Panadeine Extra Strength as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
GNH USA supplies Panadeine Extra Strength as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
What is Paracetamol, Codeine Phosphate Hemihydrate used for?
Panadeine Extra Strength combines paracetamol and codeine phosphate to relieve pain through central nervous system pathways.
- Headache: Provides relief from tension‑type and migraine‑associated pain. - Dental pain: Reduces discomfort following extractions or dental procedures. - Musculoskeletal pain: Alleviates aches from strains, sprains and low‑back pain. - Post‑operative pain: Helps manage pain after minor surgical procedures. - Fever: Lowers elevated body temperature associated with infection or inflammation.
What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?
Paracetamol/codeine may cause a range of adverse reactions, most of which are dose‑dependent.
Common Side Effects: - Nausea: Mild to moderate stomach upset. - Drowsiness: Feelings of sleepiness or reduced alertness. - Constipation: Reduced bowel movements, especially with prolonged use. - Dizziness: Light‑headed feeling, particularly when standing quickly. - Dry mouth: Reduced salivation causing throat discomfort.
Serious or Rare Side Effects: - Respiratory depression: Shallow breathing, especially at higher opioid doses. - Hepatotoxicity: Liver injury from excessive paracetamol exposure. - Allergic reactions: Rash, itching, swelling or anaphylaxis. - Seizures: Rare occurrence, often linked to overdose. - Dependence or withdrawal: Potential for opioid‑related dependence with prolonged use.
What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?
When using Panadeine Extra Strength, consider the following safety measures:
- Dose limits: Do not exceed the maximum daily paracetamol amount recommended for adults. - Alcohol use: Avoid concurrent excessive alcohol consumption, which increases liver risk. - Liver function: Assess hepatic health before initiating therapy in patients with known liver disease. - Opioid sensitivity: Monitor for signs of opioid sensitivity or dependence, especially in opioid‑naïve individuals. - Pregnancy and lactation: Use only if clearly needed and prescribed by a healthcare professional. - Store at ambient temperature: Keep below 25°C, in the original packaging, protected from moisture and direct sunlight.
What does Paracetamol, Codeine Phosphate Hemihydrate interact with?
Panadeine Extra Strength can interact with several medicines, requiring careful management.
Major Interactions (Avoid): - CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): May increase codeine levels and risk of toxicity. - Hepatotoxic drugs (e.g., isoniazid, high‑dose acetamin acetylacetate): Heightened risk of liver injury. - Central nervous system depressants (e.g., benzodiazepines, alcohol): Additive sedation and respiratory depression.
Moderate Interactions (Monitor Closely): - Anticoagulants (e.g., warfarin): May enhance anticoagulant effect, requiring INR monitoring. - Antihistamines: May increase drowsiness. - Diuretics: Potential for reduced renal clearance of paracetamol metabolites.
