Europe — EMA
Palonosetron Accord
Palonosetron, the active ingredient in Palonosetron Accord, is a 5‑HT₃ receptor antagonist presented as a strength/form for intravenous use.
Request sourcing
What is Palonosetron?
Palonosetron, the active ingredient in Palonosetron Accord, is a 5‑HT₃ receptor antagonist presented as a strength/form for intravenous use. It is used to prevent nausea and vomiting associated with chemotherapy and surgery in adult patients. GNH USA supplies Palonosetron Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.
GNH USA supplies Palonosetron Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.
What is Palonosetron used for?
Palonosetron is indicated for the prevention of chemotherapy‑induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). It works within the serotonergic pathway to reduce emesis.
- Chemotherapy‑induced nausea and vomiting: provides effective prophylaxis for acute and delayed phases. - Post‑operative nausea and vomiting: reduces incidence of nausea and vomiting after general anesthesia. - Radiotherapy‑induced nausea and vomiting: helps control nausea associated with radiation treatment.
What are the side effects of Palonosetron?
Palonosetron may cause a range of adverse reactions, most of which are mild to moderate in intensity.
Common Side Effects: - Headache: mild to moderate intensity. - Constipation: occasional bowel movement changes. - Fatigue: general feeling of tiredness. - Dizziness: transient light‑headedness. - Injection site reactions: erythema or mild pain.
Serious or Rare Side Effects: - Hypersensitivity reactions: rash, pruritus, or anaphylaxis. - Cardiac arrhythmias: QT‑interval prolongation. - Severe constipation or intestinal obstruction. - Serotonin syndrome: rare when combined with other serotonergic agents. - Neurotoxicity: rare central nervous system effects.
What precautions apply to Palonosetron?
When using Palonosetron, certain precautions should be observed to ensure safe administration.
- Assess patient history: evaluate for prior hypersensitivity to 5‑HT₃ antagonists. - Monitor cardiac status: consider ECG monitoring in patients with known QT prolongation. - Review concomitant medications: avoid drugs that may prolong QT interval. - Adjust for renal/hepatic impairment: dose may need modification in severe dysfunction. - Pregnancy and lactation: use only if clearly needed. - Store at ambient temperature: keep below 25°C, protect from moisture and light.
What does Palonosetron interact with?
Palonosetron interacts primarily … ... ...
Major --- ... … ... ... … t t ",
