Europe — EMA
Paliperidona Teva (Paliperidone Palmitate)
Paliperidone palmitate, the active ingredient in Paliperidona Teva, is an atypical antipsychotic presented as an intramuscular injection for depot use.
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What is Paliperidone Palmitate?
Paliperidone palmitate, the active ingredient in Paliperidona Teva, is an atypical antipsychotic presented as an intramuscular injection for depot use. It is indicated for the treatment of schizophrenia in adults and for maintenance therapy to reduce relapse risk.
GNH USA supplies Paliperidona Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Paliperidone Palmitate used for?
Paliperidone palmitate is an atypical antipsychotic used in the schizophrenia treatment pathway. - Schizophrenia: Improves psychotic symptoms and helps maintain stability over the long term. - Schizoaffective disorder: Reduces mood‑related symptoms and psychosis. - Maintenance therapy after acute episode: Prevents relapse and hospitalization.
What are the side effects of Paliperidone Palmitate?
Paliperidone palmitate may cause a range of adverse reactions that vary in frequency and severity.
Common Side Effects: - Injection site pain or erythema - Headache - Fatigue - Restlessness or akathisia - Weight gain - Increased prolactin levels
Serious or Rare Side Effects: - Neuroleptic malignant syndrome - Tardive dyskinesia - Severe hypotension - Seizures - Agranulocytosis - Hyperglycaemia or new‑onset diabetes
What precautions apply to Paliperidone Palmitate?
When prescribing paliperidone palmitate, clinicians should consider several safety aspects. - Cardiovascular assessment: Evaluate for orthostatic hypotension and monitor blood pressure. - Metabolic monitoring: Check glucose and lipid profiles regularly. - Prolactin monitoring: Assess for galactorrhoea or menstrual disturbances. - Pregnancy and lactation: Use only if benefits outweigh risks. - Renal function: Dose adjustment may be needed in severe impairment. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze.
What does Paliperidone Palmitate interact with?
Paliperidone palmitate can interact with several drug classes, requiring attention to avoid reduced efficacy or increased toxicity.
Major Interactions (Avoid): - Strong CYP3A4 inhibitors: May increase paliperidone exposure. - QT‑prolonging agents: Heightened risk of cardiac arrhythmia.
Moderate Interact ions (Monitor Closely): - Moderate CYP3A4 inducers: May lower palitos… -
