Paidofen (Ibuprofen)

Ibuprofen, the active ingredient in Paidofen, is a non‑steroidal anti‑inflammatory drug presented as a tablet for oral use. It treats pain, fever and inflammation in adults and children when appropriate.

GNH USA supplies Paidofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Paidofen is an NSAID that acts on inflammatory pathways to relieve several common conditions.

- Headache: reduces pain intensity and improves functional ability. - Dental pain: alleviates postoperative and procedural discomfort. - Musculoskeletal pain: decreases inflammation‑related soreness in joints and muscles. - Fever: lowers elevated body temperature. - Dysmenorrhea: eases menstrual cramps and associated pain.

Adverse reactions to ibuprofen may range from mild to severe.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or heartburn. - Headache: mild, transient headache. - Dizziness: occasional light‑headed feeling. - Rash: mild skin redness or itching. - Fluid retention: mild peripheral oedema.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe skin reactions such as Stevens‑Johnson syndrome. - Renal impairment or acute kidney injury. - Hepatotoxicity: elevated liver enzymes or hepatitis. - Anaphylaxis: life‑threatening allergic reaction.

When using Paidofen, consider the following safety measures:

- Assess renal function: check baseline kidney parameters in patients with existing kidney disease. - Evaluate cardiovascular risk: use caution in individuals with hypertension or heart disease. - Review gastrointestinal history: avoid in patients with active ulcers or a history of significant GI bleeding. - Monitor for asthma exacerbation: ibuprofen can trigger bronchospasm in aspirin‑sensitive individuals. - Avoid use in late pregnancy: third‑trimester exposure may affect fetal cardiovascular function. - Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Ibuprofen may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - High‑dose aspirin or other NSAIDs: additive gastrointestinal toxicity. - Selective COX‑2 inhibitors (e.g., celecoxib): heightened cardiovascular risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect. - Diuretics: may diminish diuretic‑induced natriuresis. - Lithium: ibuprofen can raise serum lithium concentrations. - Methotrexate: reduced renal clearance may increase toxicity. - Corticact