Paduden Express (Ibuprofen)

Ibuprofen, the active ingredient in Paduden Express, is a non‑steroidal anti‑inflammatory drug presented as a strength/form for oral use. It treats pain, fever and inflammation in adults and children when appropriate. GNH USA supplies Paduden Express as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen is an NSAID that reduces inflammation and pain across several common conditions.

- Headache: provides relief from mild to moderate tension‑type headaches. - Dental pain: helps manage postoperative dental discomfort. - Musculoskeletal pain: reduces pain and swelling associated with sprains, strains and minor injuries. - Fever: lowers elevated body temperature in febrile adults and children. - Menstrual cramps: eases dysmenorrhea‑related pelvic pain.

Adverse reactions to ibuprofen vary in frequency and severity.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or mild abdominal pain. - Headache: transient headache may occur. - Dizziness: occasional light‑headedness. - Rash: mild skin redness or itching. - Elevated blood pressure: slight increase in some patients.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Severe allergic reactions: anaphylaxis, angioedema. - Liver injury: marked elevation of hepatic enzymes. - Kidney impairment: acute renal failure, especially with dehydration. - Cardiovascular events: increased risk of heart attack or stroke.

Before using Paduden Express, consider the following safety measures:

- Assess gastrointestinal risk: avoid in patients with active ulcers or severe dyspepsia. - Evaluate cardiovascular health: use cautiously in those with hypertension or heart disease. - Monitor renal function: contraindicated in severe kidney impairment. - Check for drug allergies: avoid if known hypersensitivity to ibuprofen or other NSAIDs. - Pregnancy and lactation: limit use to the lowest effective duration and consult a healthcare professional. - Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture.

Ibuprofen can affect the activity of several other medicines. Review the following interaction categories:

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - High‑dose aspirin: heightened gastrointestinal toxicity. - Selective COX‑2 inhibitors (e.g., celecoxib): additive renal and cardiovascular effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihyant antihypertensive effect. - Diuretics: risk of reduced renal perfusion. - Lithium: increased serum lithium levels. - Methotrexate: decreased renal clearance leading to toxicity. - SSRIs: elevated risk of gastrointestinal bleeding.