Europe — EMA
Pabal (Carbetocin)
GNH USA supplies Pabal (Carbetocin), an oxytocin analog for preventing postpartum hemorrhage. Request a quote for global supply.
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What is Carbetocin?
Carbetocin, the active ingredient in Pabal, is an oxytocin analog presented as a sterile injectable solution for intravenous use. It is used to prevent postpartum hemorrhage in women after vaginal delivery or caesarean section. GNH USA supplies Pabal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.
GNH USA supplies Pabal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.
What is Carbetocin used for?
Carbetocin is employed in obstetric care to promote uterine contraction and reduce bleeding.
- Postpartum hemorrhage: Helps reduce the incidence of excessive bleeding after vaginal delivery. - Caesarean section recovery: Supports uterine tone following surgical birth. - Uterine atony: Assists in restoring uterine muscle tone when it is insufficient after delivery.
What are the side effects of Carbetocin?
Adverse reactions to carbetocin are generally mild to moderate and reflect its uterotonic activity.
Common Side Effects: - Nausea: Mild, transient nausea may occur. - Headache: Occasional mild headache. - Flushing: Temporary skin flushing. - Hypertension: Slight increase in blood pressure. - Tachycardia: Mild increase in heart rate.
Serious or Rare Side Effects: - Anaphylaxis: Severe allergic reaction requiring immediate medical attention. - Myocardial ischemia: Chest pain or cardiac ischemia in susceptible individuals. - Pulmonary edema: Fluid accumulation in the lungs. - Seizures: Rare neurologic events. - Severe hypotension: Marked drop in blood pressure.
What precautions apply to Carbetocin?
When using carbetocin, clinicians should assess patient history and monitor vital signs.
- Contraindications: Known allergy to carbetocin or oxytocin. - Cardiovascular monitoring: Observe blood pressure and heart rate during administration. - Fluid balance: Ensure adequate hydration to avoid hypotension. - Pre‑eclampsia/eclampsia: Use with caution in patients with these conditions. - Store at ambient temperature: Keep in original packaging, protect from light and moisture.
What does Carbetocin interact with?
Carbetocin may interact with other agents that affect cardiovascular function or uterine activity.
Major Interactions (Avoid): - Vasopressors: May exacerbate hypertension when combined. - Beta‑blockers: Can blunt heart‑rate response. - Magnesium sulfate: May potentiate uterine relaxation, reducing efficacy.
Moderate Interactions (Monitor Closely): - Antihypertensives: May require dose adjustment of carbetocin. - Diuretics: Can influence fluid status and blood pressure. - Anesthetic agents: May alter hemodynamic response during surgery.
