Europe — EMA
Pabal (Carbetocin)
GNH USA supplies Pabal (Carbetocin), a uterotonic for postpartum hemorrhage and cesarean recovery. Request a quote for global supply.
Request sourcing
What is Carbetocin?
Carbetocin, the active ingredient in Pabal, is an oxytocin analog presented as a uterotonic for injectable use. It is employed to prevent postpartum hemorrhage in women after vaginal delivery or cesarean section. GNH USA supplies Pabal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.
GNH USA supplies Pabal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.
What is Carbetocin used for?
Carbetocin is used in obstetric care to promote uterine contraction and reduce bleeding after delivery.
- Postpartum hemorrhage: Helps reduce the incidence of excessive bleeding following vaginal birth. - Cesarean section recovery: Supports uterine tone after surgical delivery, lowering blood loss. - Uterine atony: Improves uterine contractility when the uterus fails to contract adequately after delivery.
What are the side effects of Carbetocin?
Adverse reactions to carbetocin are generally mild to moderate and reflect its uterotonic activity.
Common Side Effects: - Nausea: Mild to moderate feeling of sickness. - Headache: Transient headache during the immediate post‑administration period. - Flushing: Warmth or redness of the skin, often on the face or neck. - Transient hypertension: Short‑term rise in blood pressure. - Vaginal bleeding: Slight spotting that resolves spontaneously.
Serious or Rare Side Effects: - Severe hypertension: Marked increase in blood pressure requiring medical intervention. - Cardiac arrhythmia: Abnormal heart rhythm that may need monitoring. - Anaphylaxis: Rare severe allergic reaction with hives, swelling, and respiratory difficulty. - Uterine rupture: Extremely rare tearing of the uterine wall. - Pulmonary edema: Fluid accumulation in the lungs, presenting with shortness of breath.
What precautions apply to Carbetocin?
Carbetocin should be administered by qualified healthcare professionals who can monitor maternal vital signs and uterine response.
- Contraindication: Known hypersensitivity to carbetocin or oxytocin analogs. - Cardiovascular monitoring: Observe blood pressure and heart rate during and after administration. - Fluid balance: Assess patient’s fluid status to avoid overload. - Pre‑existing hypertension: Use cautiously in patients with uncontrolled high blood pressure. - Store at ambient temperature: Keep in original packaging, protect from moisture and direct sunlight.
What does Carbetocin interact with?
Carbetocin may interact with other agents that affect cardiovascular function or uterine tone.
Major Interactions (Avoid): - Vasopressors: May exacerbate hypertension when combined with carbetocin. - β‑blockers: Can blunt heart‑rate response, complicating hemodynamic monitoring.
Moderate Interactions (Monitor Closely): - Antihypertensive drugs: May require dose adjustment of either agent. - Magnesium sulfate: Can potentiate uterine relaxation, reducing carbetocin efficacy. - Anesthetic agents: May alter uterine contractility and hemodynamic response.
