GNH USA

Europe — EMA

Oxycodon/Naloxon Krka (Naloxone Hydrochloride, Oxycodone Hydrochloride)

GNH USA supplies Oxycodon/Naloxon Krka (Naloxone/Oxycodone), an opioid analgesic for acute postoperative, cancer and chronic pain.

Naloxone Hydrochloride, Oxycodone Hydrochloride

International sale not permitted. Listed for the domestic market and B2B only.

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What is Naloxone Hydrochloride, Oxycodone Hydrochloride?

Naloxone Hydrochloride, the active ingredient in Oxycodon/Naloxon Krka, is an opioid antagonist presented as a combination formulation for oral use. It is used together with oxycodone hydrochloride to manage moderate to severe pain while reducing opioid‑induced constipation and the risk of misuse.

GNH USA supplies Oxycodon/Naloxon Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

What is Naloxone Hydrochloride, Oxycodone Hydrochloride used for?

Oxycodon/Naloxon Krka combines an opioid agonist with an antagonist to provide analgesia while limiting abuse potential. It is indicated for: - Acute postoperative pain: provides rapid, strong pain relief after surgery. - Cancer‑related pain: helps control moderate to severe pain in oncology patients. - Chronic non‑cancer pain: offers long‑term management of severe musculoskeletal or neuropathic pain when other treatments are insufficient.

What are the side effects of Naloxone Hydrochloride, Oxycodone Hydrochloride?

Common Side Effects: - Nausea: mild to moderate stomach upset. - Constipation: reduced bowel motility, though less frequent than with oxycodone alone. - Dizziness: light‑headed feeling, especially when standing. - Headache: transient cranial discomfort. - Dry mouth: reduced salivation. - Somnolence: mild sleepiness.

Serious or Rare Side Effects: - Respiratory depression: slowed breathing, potentially life‑threatening. - Severe hypotension: marked drop in blood pressure. - Hepatotoxicity: liver enzyme elevations or injury. - Allergic reactions: rash, itching, swelling, or anaphylaxis. - Opioid dependence or withdrawal: signs of physical dependence with prolonged use.

What precautions apply to Naloxone Hydrochloride, Oxycodone Hydrochloride?

Before prescribing Oxycodon/Naloxon Krka, consider the following precautions: - Assess renal and hepatic function: dosage may need adjustment in impairment. - Evaluate history of respiratory disorders: risk of respiratory depression is higher. - Monitor for signs of opioid dependence: use caution in patients with substance‑use history. - Avoid concurrent CNS depressants: increased sedation and respiratory risk. - Pregnancy and lactation: use only if benefit outweighs risk. - Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

What does Naloxone Hydrochloride, Oxycodone Hydrochloride interact with?

Oxycodon/Naloxon Krka can interact with several drug classes. Careful review of a patient’s medication list is essential.

Major Interactions (Avoid): - Other opioids: additive respiratory depression and sedation. - Benzodiazepines or barbiturates: profound CNS depression. - MAO inhibitors: risk of severe serotonin syndrome.

Moderate Interactions (Monitor Closely): - CYP3A4 inhibitors (e.g., ketoconazole): increased oxycodone levels. - CYP3A4 inducers (e.g., rifampicin): reduced analgesic effect. - Anticholinergic agents: may worsen constipation. - Diuretics: can amplify hypotensive effects.

Frequently asked questions

What is Oxycodon/Naloxon Krka used for?+
Oxycodon/Naloxon Krka is a fixed‑dose combination of oxycodone and naloxone indicated for the management of moderate to severe pain, including acute postoperative pain, cancer‑related pain and chronic non‑cancer pain, while helping to reduce opioid‑induced constipation.
How does naloxone work in this combination?+
Naloxone is a peripheral μ‑opioid receptor antagonist with low oral bioavailability. When taken with oxycodone, it blocks opioid receptors in the gastrointestinal tract, limiting constipation and other gut‑related side effects without interfering with the central analgesic action of oxycodone.
What is the usual dose of Oxycodon/Naloxon Krka?+
The dosage is individualized by the prescribing clinician based on pain severity, patient tolerance, renal and hepatic function, and prior opioid exposure. The prescriber determines the appropriate strength and dosing schedule for each patient.
Is Oxycodon/Naloxon Krka safe during pregnancy or breastfeeding?+
Use during pregnancy or lactation is only recommended when the potential benefit justifies the potential risk to the fetus or infant. Clinicians should evaluate maternal pain needs against possible adverse effects and consider alternative therapies when possible.
How do I order Oxycodon/Naloxon Krka from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does this product compare with other opioid analgesics?+
Compared with single‑agent opioids, the oxycodone‑naloxone combo offers comparable analgesia while reducing the incidence of opioid‑induced constipation. It provides a built‑in strategy to mitigate a common side effect, which can improve patient adherence and quality of life versus opioids without an antagonist.
What are the storage and handling requirements for Oxycodon/Naloxon Krka?+
Store the product below 25 °C in its original packaging, protecting it from moisture and direct sunlight. Ensure the container is tightly closed to maintain tablet integrity and potency throughout its shelf life.
How is Oxycodon/Naloxon Krka administered?+
The medication is taken orally, usually with water. It may be administered with or without food, but consistent intake with respect to meals helps maintain stable drug levels. Patients should follow the prescribing clinician’s instructions regarding timing and frequency.
What are the most serious risks associated with this medication?+
The most serious risks include respiratory depression, severe hypotension, hepatotoxicity, and the potential for opioid dependence or withdrawal. Immediate medical attention is required if signs of respiratory compromise, extreme drowsiness, or allergic reactions occur.
Who should not use Oxycodon/Naloxon Krka?+
Patients with known hypersensitivity to oxycodone, naloxone or any excipients, those with severe respiratory insufficiency, uncontrolled asthma, or significant gastrointestinal obstruction should avoid this product. It is also contraindicated in individuals taking monoamine oxidase inhibitors.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Naloxone Hydrochloride, Oxycodone Hydrochloride
Route
Oral Use
Manufacturer
Krka, D.D., Novo Mesto
Origin
EU

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