GNH USA

Europe — EMA

Novain 4 Mg/Ml Colírio, (Oxybuprocaine Hydrochloride)

GNH USA supplies Novain 4 Mg/Ml Colírio (Oxybuprocaine Hydrochloride), an ophthalmic anesthetic for eye exams, surgery and abrasion relief. Request a quote.

Oxybuprocaine Hydrochloride

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What is Oxybuprocaine Hydrochloride?

Oxybuprocaine Hydrochloride, the active ingredient in Novain 4 Mg/Ml Colírio, is a local anesthetic (ester type) presented as a 4 mg/mL eye drop for ocular topical use. It provides temporary surface anesthesia for diagnostic procedures, minor eye surgery, and corneal abrasion pain relief.

GNH USA supplies Novain 4 Mg/Ml Colírio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Oxybuprocaine Hydrochloride used for?

Oxybuprocaine Hydrochloride is used as an ophthalmic anesthetic for temporary surface numbness in ocular procedures.

Diagnostic ocular procedures: provides rapid, reversible anesthesia to facilitate examination. Minor eye surgery: enables pain‑free performance of procedures such as foreign body removal. Corneal abrasion: relieves pain associated with superficial corneal injuries.

What are the side effects of Oxybuprocaine Hydrochloride?

Oxybuprocaine Hydrochloride may cause local ocular reactions, most of which are mild and transient.

Common Side Effects: - Burning sensation: mild stinging upon instillation. - Redness: transient conjunctival hyperemia. - Tearing: increased lacrimation. - Blurred vision: temporary visual disturbance.

Serious or Rare Side Effects: - Allergic reaction: swelling, itching, or rash around the eye. - Corneal ulceration: persistent epithelial defect. - Anaphylaxis: systemic allergic response (extremely rare).

What precautions apply to Oxybuprocaine Hydrochloride?

Use Novain only when indicated and observe the following precautions. - Indication verification: ensure appropriate ocular procedure before use. - Allergy assessment: check for hypersensitivity to ester‑type anesthetics. - Contact lens use: remove lenses prior to instillation. - Repeated dosing: limit frequency to avoid corneal toxicity. - Pediatric use: exercise caution; use only under specialist supervision. - Store at ambient temperature: keep in original container, protect from light and moisture.

What does Oxybuprocaine Hydrochloride interact with?

Consider potential drug interactions when co‑administering ocular preparations.

Major Interactions (Avoid): - Anticholinergic eye drops: may reduce drug absorption. - Systemic anesthetics: additive CNS depression (though minimal ocular exposure). - Topical antibiotics with preservatives: increased risk of ocular irritation.

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory eye drops: may alter corneal healing. - Other topical ocular anesthetics: risk of cumulative toxicity. - Preservative‑containing solutions: monitor for irritation.

Frequently asked questions

What is Novain 4 Mg/Ml Colírio used for?+
Novain 4 Mg/Ml Colírio is an ophthalmic anesthetic containing Oxybuprocaine Hydrochloride, used to provide temporary surface numbness for diagnostic ocular examinations, minor eye surgeries, and relief of pain from corneal abrasions. The drug is applied as eye drops directly onto the ocular surface under professional supervision.
How does Oxybuprocaine Hydrochloride work?+
Oxybuprocaine Hydrochloride blocks voltage‑gated sodium channels in peripheral nerve membranes of the corneal epithelium, preventing the initiation and propagation of nerve impulses. This reversible blockade stops the transmission of pain signals, producing rapid, short‑lasting anesthesia of the ocular surface.
What is the usual dose of Novain 4 Mg/Ml Colírio?+
The dosing regimen for Novain 4 Mg/Ml Colírio is determined by the prescribing clinician based on the specific procedure and patient needs. Typically, one to two drops are instilled in the affected eye shortly before the intended diagnostic or surgical intervention.
Is Novain safe to use during pregnancy or breastfeeding?+
Safety data for Oxybuprocaine Hydrochloride in pregnancy and lactation are limited, and the product’s pregnancy category is not established. Consequently, it should be used only if the potential benefit justifies any possible risk to the fetus or infant, and under medical guidance.
How do I order Novain 4 Mg/Ml Colírio from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does Novain compare with other ophthalmic anesthetics?+
Novain contains Oxybuprocaine Hydrochloride, an ester‑type local anesthetic, which provides rapid onset and short duration of action similar to other agents such as proparacaine or tetracaine. Compared with amide‑type anesthetics, ester agents may have a slightly higher risk of allergic reactions but are widely used for brief procedures due to their predictable profile.
What are the storage requirements for Novain 4 Mg/Ml Colírio?+
Novain should be stored at ambient temperature, preferably below 25 °C, in its original container. Protect the bottle from direct sunlight, moisture, and extreme temperature fluctuations. Keep the product out of reach of children and discard any solution that appears discolored or contains particles.
How is Novain administered?+
The medication is supplied as sterile eye drops. The patient or clinician instills one to two drops onto the conjunctival sac of the target eye, typically a few minutes before the planned procedure. The eye should be gently closed for a brief period to allow even distribution of the anesthetic across the ocular surface.
What are the most serious risks associated with Novain?+
Although rare, serious adverse events can include allergic reactions such as swelling, itching, or rash around the eye, corneal ulceration from prolonged exposure, and systemic anaphylaxis. Any signs of severe eye pain, vision loss, or systemic allergic response require immediate medical attention and discontinuation of the product.
Who should not use Novain 4 Mg/Ml Colírio?+
Individuals with known hypersensitivity to Oxybuprocaine, other ester‑type local anesthetics, or any component of the formulation should avoid using Novain. It is also contraindicated in patients with active corneal infections, severe ocular surface disease, or when contact lenses are in place unless removed prior to administration.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Oxybuprocaine Hydrochloride
Route
Ocular Use
Manufacturer
Agepha Pharma S.R.O
Origin
EU

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