Europe — EMA
Oxbryta (Voxelotor)
Voxelotor, the active ingredient in Oxbryta, is a hemoglobin oxygen‑binding modulator presented as a tablet for oral use. It is indicated for the treatment of sickle cell disease in adults and pediatric patients aged 12…
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What is Voxelotor?
Voxelotor, the active ingredient in Oxbryta, is a hemoglobin oxygen‑binding modulator presented as a tablet for oral use. It is indicated for the treatment of sickle cell disease in adults and pediatric patients aged 12 years and older. GNH USA supplies Oxbryta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
GNH USA supplies Oxbryta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
What is Voxelotor used for?
Oxbryta is used in the management of sickle cell disease, a genetic disorder affecting hemoglobin.
- Sickle cell disease: Improves hemoglobin levels and reduces hemolysis. - Sickle cell-related vaso‑occlusive crises: May lower the frequency of painful episodes. - Chronic anemia in sickle cell disease: Contributes to better oxygen transport and quality of life.
What are the side effects of Voxelotor?
Adverse reactions reported with Oxbryta are generally mild to moderate.
Common Side Effects: - Headache - Diarrhea - Nausea - Fatigue - Abdominal pain - Dizziness
Serious or Rare Side Effects: - Liver enzyme elevation (ALT/AST) - Severe allergic reactions (anaphylaxis) - Hemolytic crisis - Thromboembolic events - Acute chest syndrome - Severe rash or Stevens‑Johnson syndrome
What precautions apply to Voxelotor?
Before using Oxbryta, consider the following safety measures:
- Monitor : Regular - Contra‑indication : Not recommended for patients with severe liver impairment. - Pregnancy : Use only if the potential benefit outweigh the risk to the fetus. - Breastfeeding : Caution due to potential exposure through milk but data limited. - Drug interaction : Review all concomitant medications for potential pharmacokinetic interactions. - Store at below 25°C: keep the tablet in the original pack and protect from moisture.
What does Voxelotor interact with?
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