Oxatrex (Ofloxacin)

Ofloxacin, the active ingredient in Oxatrex, is a fluoroquinolone antibiotic presented as a strength/form for oral use. It treats a variety of bacterial infections in adults and children when prescribed by a healthcare professional.

GNH USA supplies Oxatrex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Oxatrex is a fluoroquinolone antibiotic that targets bacterial DNA replication pathways. It is commonly used for: - Urinary tract infections: helps eradicate *E. coli* and other common uropathogens. - Respiratory tract infections: effective against *Streptococcus pneumoniae*, *Haemophilus influenzae* and atypical organisms. - Skin and soft‑tissue infections: aids in clearing *Staphylococcus aureus* and *Streptococcal* species. - Gonorrhoea: used as a single‑dose therapy for uncomplicated *Neisseria gonorrhoeae* infection.

Ofloxacin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild stomach upset that usually resolves without treatment. - Diarrhea: loose stools that may improve with hydration. - Headache: transient cranial discomfort. - Dizziness: occasional light‑headedness, especially on standing. - Photosensitivity: increased skin sensitivity to sunlight. - Abdominal pain: cramping or discomfort in the stomach area.

Serious or Rare Side Effects: - Tendon rupture: sudden pain or swelling in tendons, most often the Achilles. - QT interval prolongation: irregular heart rhythm detectable on ECG. - Severe allergic reaction: rash, itching, swelling, or difficulty breathing. - Central nervous system effects: seizures or psychosis in susceptible individuals. - Hepatotoxicity: elevated liver enzymes or jaundice. - Peripheral neuropathy: tingling or numbness in extremities.

When prescribing Oxatrex, clinicians should consider patient‑specific factors and monitor for known risks.

- Tendon health: avoid use in patients with a history of tendon disorders or who are on corticosteroids. - Cardiac monitoring: caution in patients with known QT prolongation or electrolyte imbalances. - Renal function: adjust use in severe renal impairment. - Pregnancy and lactation: contraindicated unless the benefit outweighs the risk. - Age considerations: use with caution in children and the elderly. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Oxatrex can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid): - Antacids containing aluminium or magnesium: reduce ofloxacin absorption. - Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase risk of CNS stimulation. - Warfarin: may enhance anticoagulant effect, requiring INR monitoring. - Theophylline: heightened risk of seizures. - Cyclosporine: increased risk of nephrotoxicity.

Moderate Interactions (Monitor Closely): - Oral contraceptives: reduced hormonal efficacy, advise backup contraception. - Diabetic agents: potential alteration of blood glucose control. - Corticosteroids: additive risk of tendon injury. - Antidiabetic sulfonylureas: possible hypoglycaemia. - Rifampicin: may lower ofloxacin plasma levels.