GNH USA

Europe — EMA

Ovestin (Estriol)

GNH USA supplies Ovestin (Estriol), an estrogen hormone for menopause symptom relief and vaginal atrophy. Request a quote for global supply.

Estriol

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1
Pack/s

What is Estriol?

Estriol, the active ingredient in Ovestin, is an estrogen hormone presented as a 0.5 mg/1 tablet for oral use. It treats estrogen deficiency symptoms in postmenopausal women and other hormone‑related conditions.

GNH USA supplies Ovestin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

What is Estriol used for?

Ovestin is an estrogen therapy that acts on hormonal pathways involved in menopause and related conditions. - Menopause symptom relief: Improves vasomotor symptoms such as hot flashes and night sweats. - Vaginal atrophy: Restores vaginal epithelium and reduces dryness. - Osteoporosis prevention: Contributes to bone density maintenance in postmenopausal women.

What are the side effects of Estriol?

Adverse reactions to estradiol‑containing products vary with dose and route of administration.

Common Side Effects: - Nausea: Mild to moderate gastrointestinal upset. - Breast tenderness: Localized discomfort or swelling. - Headache: Tension‑type or migraine‑like pain. - Fluid retention: Mild peripheral edema. - Mood changes: Irritability or mild depressive symptoms.

Serious or Rare Side Effects: - Thromboembolic events: Deep‑vein thrombosis or pulmonary embolism. - Stroke: Ischemic or hemorrhagic cerebrovascular accident. - Hepatotoxicity: Elevated liver enzymes or jaundice. - Hormone‑dependent cancer progression: Potential stimulation of breast or endometrial tumors. - Severe allergic reaction: Anaphylaxis or angio‑edema.

What precautions apply to Estriol?

When prescribing estradiol products, clinicians should consider several safety aspects. - Cardiovascular risk assessment: Evaluate history of thromboembolism, stroke, or myocardial infarction. - Cancer screening: Perform regular breast and endometrial examinations. - Liver function monitoring: Check enzymes in patients with hepatic impairment. - Hormone‑sensitive conditions: Use caution in women with a history of estrogen‑dependent tumors. - Drug‑interaction review: Assess concomitant medications that affect coagulation or hormone metabolism. - Store at ambient temperature: Keep below 25°C in the original packaging, protected from moisture.

What does Estriol interact with?

Estradiol may interact with a range of medicines that alter its metabolism or increase clotting risk.

Major Interactions (Avoid): - Warfarin: Potentiates anticoagulant effect and raises bleeding risk. - Combined oral contraceptives: Increases estrogen load, heightening thrombotic potential. - GnRH agonists: May blunt therapeutic response and alter hormone levels.

Moderate Interactions (Monitor Closely): - Antifungal azoles (ketoconazole, itraconazole): Reduce estradiol clearance. - Antiretroviral protease inhibitors: May increase estradiol plasma concentrations. - Selective serotonin reuptake inhibitors (SSRIs): Can affect estradiol metabolism and mood‑related side effects.

Frequently asked questions

What is Ovestin used for?+
Ovestin contains estriol, an estrogen hormone used to treat symptoms of estrogen deficiency such as hot flashes, vaginal dryness, and bone loss in postmenopausal women. It is prescribed as part of hormone‑replacement therapy to improve quality of life during menopause.
How does estriol work in the body?+
Estriol binds to estrogen receptors (ERα and ERβ) in target tissues, activating gene transcription that regulates reproductive, skeletal and mucosal functions. This receptor‑mediated activity restores estrogen‑dependent processes, reducing vasomotor symptoms and supporting vaginal and bone health.
What is the usual dose of Ovestin?+
The specific dose of Ovestin is determined by the prescribing clinician based on the patient’s condition, age, and response to therapy. Healthcare providers set the appropriate strength and dosing schedule according to clinical guidelines.
Is Ovestin safe to use during pregnancy or breastfeeding?+
Estriol is a hormone that can affect fetal development; therefore, Ovestin is generally not recommended during pregnancy unless clearly needed. Breastfeeding mothers should consult their physician, as estrogen can pass into breast milk and potentially influence infant hormonal balance.
How do I order Ovestin from GNH USA?+
To request Ovestin, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and import documentation.
How does Ovestin compare with other estrogen therapies?+
Ovestin’s active ingredient estriol is a weaker estrogen compared with estradiol‑based products, offering a potentially lower risk of estrogen‑related adverse events while still providing symptom relief. Choice of therapy depends on individual risk profiles, severity of symptoms and clinician preference.
What are the storage requirements for Ovestin?+
Store Ovestin tablets at ambient temperature, below 25 °C, in the original packaging. Protect the product from moisture and direct sunlight to maintain potency throughout its shelf life.
How is Ovestin administered?+
Ovestin is supplied as an oral tablet that is taken by mouth with or without food, as directed by the prescribing healthcare professional. Swallow the tablet whole; do not crush or split unless instructed.
What are the most serious risks associated with Ovestin?+
Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, stroke, and possible stimulation of hormone‑dependent cancers. Patients should be monitored for signs of blood clots, neurological changes, or abnormal uterine bleeding.
Who should not use Ovestin?+
Women with a history of estrogen‑dependent cancers, active or past thromboembolic disease, uncontrolled hypertension, liver disease, or known hypersensitivity to estriol should avoid Ovestin. A thorough medical assessment is required before initiating therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Estriol
Route
Vaginal Use
Manufacturer
Aspen Pharma Trading Limited
Origin
EU

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