Europe — EMA
Otrivin (Xylometazoline Hydrochloride)
Xylometazoline hydrochloride, the active ingredient in Otrivin, is an Alpha‑2‑adrenergic agonist presented as a nasal spray for topical intranasal use.
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What is Xylometazoline Hydrochloride?
Xylometazoline hydrochloride, the active ingredient in Otrivin, is an Alpha‑2‑adrenergic agonist presented as a nasal spray for topical intranasal use. It relieves nasal congestion caused by colds, sinusitis and allergic rhinitis in adults and children. GNH USA supplies Otrivin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
GNH USA supplies Otrivin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Xylometazoline Hydrochloride used for?
Otrivin is an alpha‑2‑adrenergic agonist that reduces nasal airway resistance in several upper‑respiratory conditions.
- Common cold: temporary relief of nasal congestion. - Acute sinusitis: decreases swelling of the nasal mucosa. - Allergic rhinitis: eases blockage caused by allergic inflammation. - Nasal surgery recovery: helps maintain airway patency post‑operatively.
What are the side effects of Xylometazoline Hydrochloride?
Adverse reactions are generally mild and related to local irritation of the nasal mucosa.
Common Side Effects: - Burning sensation: mild burning or stinging at the application site. - Nasal dryness: dryness or crusting inside the nose. - Sneezing: transient sneezing after spray use. - Headache: mild headache in some users. - Epistaxis: occasional nosebleeds. - Taste disturbance: altered taste perception.
Serious or Rare Side Effects: - Severe nasal irritation: intense burning or ulceration. - Rebound congestion: worsening nasal blockage after prolonged use. - Allergic reaction: rash, itching, swelling or difficulty breathing. - Hypertension: elevated blood pressure in susceptible individuals. - Cardiac arrhythmia: irregular heartbeat in rare cases. - Anaphylaxis: life‑threatening systemic allergic response.
What precautions apply to Xylometazoline Hydrochloride?
Before using Otrivin, consider the following safety measures:
- Age restriction: not recommended for children under 6 years without medical advice. - Duration limit: limit usage to 3‑7 days to avoid rebound congestion. - Pre‑existing conditions: use cautiously in patients with hypertension, heart disease, diabetes mellitus. - Pregnancy and lactation: consult the professional for risk assessment before use. - Drug interactions: review concomitant nasal medications before use. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.
What does Xylometazoline Hydrochloride interact with?
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