Ostine (Calcium Carbonate, Cholecalciferol Concentrate (Powder Form))

Calcium carbonate, the active ingredient in Ostree, is a calcium supplement presented as a powder for oral use. It supports bone health and calcium balance in adults and children with increased needs.

GNH USA supplies Ostine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ostine is a calcium supplement that addresses conditions related to calcium deficiency and bone metabolism: - Osteoporosis: helps maintain bone mineral density and reduces fracture risk. - Hypocalcaemia: restores normal serum calcium levels. - Rickets/osteomalacia: provides essential calcium for bone mineralisation in children and adults. - Post‑menopausal bone loss: assists in preserving bone strength during hormonal changes. - Dietary calcium insufficiency: supplements daily calcium intake when diet is inadequate.

Adverse reactions to calcium carbonate and vitamin D3 are generally mild and dose‑dependent.

Common Side Effects: - Constipation: reduced bowel motility. - Flatulence: excess gas production. - Nausea: mild stomach upset. - Abdominal discomfort: cramping or pain. - Hypercalcemia (mild): elevated serum calcium levels.

Serious or Rare Side Effects: - Severe hypercalcemia: confusion, arrhythmia, renal impairment. - Kidney stones: calcium oxalate crystallisation. - Allergic reaction: rash, itching, swelling, or anaphylaxis. - Hypervitaminosis D: excessive vitamin D leading to toxicity. - Pancreatitis: inflammation of the pancreas in rare cases.

When using Ostine, consider the following safety measures: - Renal impairment: adjust dose and monitor serum calcium. - Hypercalcemia risk: avoid use if baseline calcium is high. - Gastrointestinal disorders: monitor for constipation or upset. - Pregnancy and lactation: use only if prescribed after risk‑benefit assessment. - Drug interactions: review concomitant medications for calcium binding. - Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Calcium carbonate can affect the absorption and efficacy of several medicines:

Major Interactions (Avoid): - Tetracycline antibiotics: reduced absorption leading to therapeutic failure. - Fluoroquinolone antibiotics: chelation reduces antibiotic levels. - Bisphosphonates: concurrent intake lowers bisphosphonate absorption.

Moderate Interactions (Monitor Closely): - Levothyroxine: calcium may decrease thyroid hormone absorption; separate dosing by 4 hours. - Iron supplements: calcium competes for intestinal uptake; stagger timing. - Loop diuretics: may increase calcium reabsorption and risk of hyper‑calcemia.