Osan Plus (Hydrochlorothiazide, Telmisartan)

Hydrochlorothiazide, the active ingredient in Osan Plus, is a thiazide diuretic presented as a combination tablet for oral use. It treats hypertension, often in combination with an angiotensin II receptor blocker, and is prescribed for adults. GNH USA supplies Osan Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH USA supplies Osan Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Osan Plus combines the diuretic hydrochlorothiazide with the ARB teltel it acts on blood‑pressure regulation pathways. It is indicated for: - Essential hypertension: lowers systolic and diastolic blood pressure when monotherapy is insufficient. - Hypertension with fluid retention: improves blood‑pressure control and reduces peripheral edema. - Diabetic nephropathy : slows the progression of renal impairment associated with diabetes. - Chronic kidney : helps manage blood‑pressure in patients with chronic kidney disease. - Heart failure : aids in reducing after‑load and symptomatic fluid overload. - Stroke risk reduction : contributes to lowering the risk of stroke in high‑risk hypertensive patients.

Osan Plus may cause a range of adverse reactions. Monitoring and patient education are essential.

Common Side Effects: - Increased urination: more frequent need to void. - Electrolyte imbalance: low potassium or sodium levels. - Dizziness or light‑headedness: especially after standing. - Headache: mild to moderate intensity. - Fatigue: general feeling of tiredness. - Elevated blood glucose: modest rise in fasting glucose.

Serious or Rare Side Effects: - Severe electrolyte disturbances: hyperkalemia or hyponatremia. - Acute kidney injury: sudden decline in renal function. - Allergic reactions: rash, itching, swelling, or anaphylaxis. - Liver enzyme elevation: abnormal liver function tests. - Blood cell disorders: neutropenia or thrombocytopenia. - Severe hypotension: marked drop in blood pressure causing fainting.

Before starting Osan Plus, consider the following precautions: - Renal function: assess baseline kidney function and monitor regularly. - Electrolyte levels: check serum potassium and sodium before and during therapy. - Diabetes: monitor blood glucose as thiazides may raise glucose levels. - Gout: be aware of potential uric acid increase that could trigger attacks. - Pregnancy and lactation: avoid use unless clearly needed; discuss risks with a healthcare professional. - Store at ambient temperature: keep below 25°C, protect from moisture and light, and retain in original packaging.

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Major  ​ ​ ​ ​ ​ - Concomitant use with other potent diuretics: risk of severe dehydration and electrolyte loss. - Co‑administration with ACE inhibitors or other ARBs: additive blood‑pressure lowering, risk of hypotension. - Lithium therapy: thiazides reduce lithium clearance, increasing toxicity risk. - NSAIDs: may blunt antihypertensive effect and impair renal function. - Cyclosporine or tacrolimus: increased risk of nephrotoxicity.

Moderate ​  - Beta‑blockers: may enhance hypotensive effect. - Antidiabetic drugs: thiazides may raise blood glucose, requiring dose adjustment. - Anticoagulants (warfarin): thiazides can alter INR stability.",