Orudis (Ketoprofen)

Ketoprofen, the active ingredient in Orudis, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It is used to relieve mild to moderate pain, reduce inflammation, and improve mobility in conditions such as arthritis and postoperative discomfort.

GNH USA supplies Orudis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen belongs to the NSAID class and is employed to manage inflammatory and painful conditions. - Rheumatoid arthritis: reduces joint inflammation and pain, improving function. - Osteoarthritis: alleviates joint stiffness and discomfort. - Acute musculoskeletal pain: provides rapid pain relief. - Post‑operative pain: helps control pain after surgical procedures. - Dysmenorrhea: eases menstrual cramps and associated pain.

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild stomach upset after dosing. - Dyspepsia: indigestion or heartburn. - Headache: transient cranial discomfort. - Dizziness: occasional light‑headedness. - Skin rash: mild erythema or itching. - Diarrhoea: loose stools.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Renal impairment or reduced kidney function. - Hepatic dysfunction or elevated liver enzymes. - Severe skin reactions such as Stevens‑Johnson syndrome. - Anaphylactic shock: rapid allergic response. - Cardiovascular events: increased risk of thrombosis.

When prescribing ketoprofen, clinicians should consider several safety measures. - Gastro‑intestinal risk: assess history of ulcers before use. - Renal function: monitor creatinine in patients with kidney disease. - Cardiovascular caution: avoid in patients with uncontrolled hypertension or heart failure. - Hypersensitivity: do not use in individuals allergic to NSAIDs. - Pregnancy: avoid in the third trimester due to fetal risk. - Use the lowest effective dose for the shortest duration. - Store at ambient temperature: keep in the original pack, protect from moisture.

Ketoprofen can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or aspirin: additive gastrointestinal toxicity. - Corticosteroids: heightened ulcer risk. - ACE inhibitors or ARBs: possible renal function decline. - Lithium: elevated lithium levels, risk of toxicity.

Moderate Interactions (Monitor Closely): - Diuretics: may reduce renal perfusion. - Methotrexate: decreased clearance, potential toxicity. - SSRIs: modest increase in bleeding tendency. - Antihypertensives: possible reduction in blood pressure control. - Oral hypoglycemics: altered glucose control.