Orudis (Ketoprofen)

Ketoprofen, the active ingredient in Orudis, is a non‑steroidal anti‑inflammatory drug presented as a 50 mg tablet for oral use. It relieves pain and inflammation associated with musculoskeletal disorders, osteoarthritis and rheumatoid arthritis in adults.

GNH USA supplies Orudis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen is an NSAID that reduces inflammation and pain in several musculoskeletal conditions. - Osteoarthritis: decreases joint pain and improves mobility. - Rheumatoid arthritis: lessens joint swelling and stiffness. - Ankylosing spondylitis: alleviates spinal pain and inflammation. - Acute musculoskeletal injury: provides short‑term pain relief and reduces swelling. - Post‑operative pain: helps control pain after minor surgical procedures.

Ketoprofen may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Dyspepsia: mild stomach discomfort or heartburn. - Nausea: feeling of queasiness. - Headache: transient head pain. - Dizziness: light‑headed sensation. - Edema: mild swelling of the ankles or feet.

Serious or Rare Side Effects: - Gastrointestinal ulcer or bleeding: severe stomach pain or black stools. - Renal impairment: reduced urine output or swelling. - Hepatotoxicity: jaundice or abnormal liver tests. - Severe skin reactions: rash, Stevens‑Johnson syndrome. - Anaphylaxis: sudden difficulty breathing or swelling of the face.

When using Ketoprofen, consider the following safety measures: - Assess renal function: check baseline creatinine in patients with kidney disease. - Monitor hepatic status: avoid use in active liver disease. - Evaluate cardiovascular risk: NSAIDs may increase thrombotic events. - Use gastro‑protective agents: consider PPIs for patients with ulcer history. - Avoid in late pregnancy: risk of fetal ductus arteriosus closure. - Store at below 25°C: keep in the original packaging, protect from moisture and light.

Ketoprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding. - ACE inhibitors / ARBs: may reduce renal perfusion.

Moderate Interactions (Monitor Closely): - Diuretics: potential for reduced kidney function. - Lithium: increased lithium levels. - Methotrexate: decreased clearance, raising toxicity risk.