Orudis (Ketoprofen)

Ketoprofen, the active ingredient in Orudis, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a tablet for oral use. It is employed to relieve pain and reduce inflammation in conditions such as arthritis and musculoskeletal injuries. GNH USA supplies Orudis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen is an NSAID that acts on inflammatory pathways to manage pain and swelling. - Rheumatoid arthritis: reduces joint pain, swelling and stiffness. - Osteoarthritis: alleviates chronic joint discomfort and improves mobility. - Acute musculoskeletal pain: provides rapid relief of sprains, strains and back pain. - Dysmenorrhea: lessens menstrual cramps and associated pelvic pain.

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or pruritus. - Elevated liver enzymes. - Fluid retention or mild edema.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Acute renal failure or worsening of chronic kidney disease. - Severe hypersensitivity reactions, including anaphylaxis. - Hepatotoxicity with jaundice. - Cardiovascular events such as myocardial infarction or stroke. - Hematologic abnormalities like thrombocytopenia.

When prescribing or dispensing Ketoprofen, consider the following precautions. - Assess gastrointestinal risk: avoid in patients with a history of ulcers or bleeding. - Monitor renal function: use cautiously in those with impaired kidney function. - Avoid use in the third trimester of pregnancy due to fetal risk. - Use with caution when combined with anticoagulants or antiplatelet agents. - Discontinue if signs of hypersensitivity or severe skin reactions appear. - Store at ambient temperature: keep in the original pack, protect from moisture.

Ketoprofen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or aspirin: heightened gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding potential. - ACE inhibitors or ARBs: possible reduction in renal function. - Lithium: increased lithium serum levels.

Moderate Interactions (Monitor Closely): - Diuretics: may impair renal clearance. - Methotrexate: reduced elimination leading to toxicity. - Cyclosporine: enhanced nephrotoxic effect. - Beta‑blockers: potential reduction in antihypertensive efficacy. - Corticosteroids: additive risk of gastrointestinal ulceration.