Orudis (Ketoprofen)

Ketoprofen, the active ingredient in Orudis, is a nonsteroidal anti‑inflammatory drug presented as a topical formulation for topical use. It treats musculoskeletal pain, osteoarthritis, rheumatoid arthritis, sprains and strains in adults.

GNH USA supplies Orudis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen acts as a topical NSAID to relieve inflammation and pain in musculoskeletal conditions. - Musculoskeletal pain: provides localized analgesic and anti‑inflammatory relief. - Osteoarthritis: reduces joint inflammation and improves mobility. - Rheumatoid arthritis: alleviates joint swelling and discomfort. - Sprains and strains: eases soft‑tissue inflammation and pain.

Ketoprofen may cause a range of local and systemic adverse reactions.

Common Side Effects: - Skin irritation: mild redness or discomfort at the application site. - Burning sensation: transient warmth or stinging after use. - Itching: pruritus localized to the treated area. - Dryness: temporary skin dryness where applied. - Erythema: mild redness without swelling.

Serious or Rare Side Effects: - Allergic reaction: hives, swelling, or difficulty breathing. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Systemic toxicity: gastrointestinal ulceration or bleeding if absorbed excessively. - Photosensitivity: heightened skin reaction to sunlight. - Contact dermatitis: persistent rash requiring medical attention.

When using topical ketoprofen, consider the following safety measures. - Avoid broken skin: do not apply to open wounds or irritated skin. - Limit area: restrict use to the recommended surface area to prevent systemic absorption. - Concomitant NSAIDs: avoid using other NSAIDs concurrently to reduce risk of adverse effects. - Pre‑existing conditions: caution in patients with a history of gastrointestinal ulceration or bleeding. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Ketoprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs or aspirin: additive gastrointestinal toxicity. - Corticosteroids: heightened risk of ulceration. - Lithium: enhanced lithium toxicity. - Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely): - Antihypertensives: possible reduction in blood pressure control. - Diuretics: potential renal function impact. - SSRIs or SNRIs: modestly increased bleeding risk. - ACE inhibitors: may affect renal perfusion. - Diabetic agents: monitor blood glucose as NSAIDs can affect glycemic control.