Orudis (Ketoprofen)

Ketoprofen, the active ingredient in Orudis, is a non‑steroidal anti‑inflammatory drug presented as a 50 mg tablet for oral use. It is indicated for the relief of mild to moderate pain and inflammation in adults. GNH USA supplies Orudis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen is a NSAID that acts on inflammatory pathways to reduce pain and swelling. - Rheumatoid arthritis: helps reduce joint pain and swelling. - Osteoarthritis: improves mobility by decreasing joint inflammation. - Acute musculoskeletal pain: provides short‑term relief of pain from sprains, strains and back pain.

Ketoprofen may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or light‑headedness. - Skin rash: mild erythema or itching. - Elevated liver enzymes: mild, transient increase.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe skin reactions such as Stevens‑Johnson syndrome. - Renal impairment or acute kidney injury. - Anaphylactic shock: rapid onset of airway swelling and hypotension. - Hepatotoxicity: marked elevation of liver enzymes or jaundice.

Ketoprofen should be used with caution in patients with certain health conditions and in specific situations. - Assess renal function: monitor renal parameters especially in the elderly. - Evaluate cardiovascular risk: use the lowest effective dose for the shortest duration. - Monitor gastrointestinal health: consider gastro‑protective agents in high‑risk patients. - Avoid use in late pregnancy: contraindicated in the third trimester. - Review concomitant medications: assess for additive NSAID effects. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Ketoprozin may interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal perfusion. - Diuretics (especially thiazides): potential for reduced efficacy of antihypertensive therapy. - Lithium: NSAIDs can increase lithium serum levels.