Orudis (Ketoprofen)

Ketoprofen, the active ingredient in Orudis, is a non‑steroidal anti‑inflammatory drug presented as a 50 mg tablet for oral use. It is indicated for the relief of mild to moderate pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis and musculoskeletal injuries in adults.

GNH USA supplies Orudis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen is a NSAID that reduces inflammation and pain in several musculoskeletal and inflammatory conditions.

- Osteoarthritis: alleviates joint pain and improves mobility. - Rheumatoid arthritis: decreases joint swelling and stiffness. - Acute musculoskeletal injury: relieves pain and reduces inflammation. - Post‑operative pain: provides short‑term analgesia after minor surgical procedures. - Dysmenorrhea: lessens menstrual cramp pain.

Ketoprofen may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or light‑headedness. - Skin rash or mild pruritus. - Elevated liver enzymes (asymptomatic).

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe skin reactions such as Stevens‑Johnson syndrome. - Renal impairment or acute kidney injury. - Hepatotoxicity with jaundice. - Anaphylaxis or severe hypersensitivity reactions.

Ketoprofen should be used with caution in patients with certain medical conditions and in specific situations.

- Assess renal function: avoid use in severe renal impairment. - Monitor hepatic function: use cautiously in liver disease. - Evaluate cardiovascular risk: NSAIDs may increase thrombotic events. - Use lowest effective dose: limit duration to the shortest necessary period. - Avoid in late‑term pregnancy: contraindicated in the third trimester. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

Ketoprofen can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - High‑dose aspirin or other NSAIDs: additive gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding potential.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal protective effects. - Diuretics: risk of reduced kidney function. - Lithium: NSAIDs can increase lithium serum levels.