Orphacol (Cholic Acid)

Cholic Acid, the active ingredient in Orphacol, is a bile acid presented as an oral formulation for oral use. It assists in the physiological process of bile flow and supports the digestion and absorption of dietary fats in patients requiring bile acid supplementation.

GNH USA supplies Orphacol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to facilitate import and distribution across global markets.

Orphacol, a bile acid, is employed in conditions where bile flow or composition is impaired.

Primary bile acid synthesis deficiency: helps restore a normal bile acid pool and improves fat absorption. Cholestatic liver disease: supports bile flow and may alleviate symptoms of cholestasis. Fat malabsorption due to bile acid deficiency: aids digestion of dietary fats. Gallstone prevention: may reduce cholesterol saturation in bile. Post‑cholecystectomy syndrome: assists in maintaining adequate bile flow.

Common Side Effects: - Abdominal discomfort or cramping. - Diarrhea or loose stools. - Nausea or mild vomiting. - Flatulence or bloating. - Headache. - Constipation.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis, rash, swelling). - Jaundice or marked elevation of liver enzymes. - Acute pancreatitis. - Worsening of cholestasis. - Hepatic failure in predisposed individuals.

Orphacol should be used with consideration of the following precautions: - Pregnancy: consult a healthcare professional before use. - Breastfeeding: evaluate risk versus benefit. - Renal impairment: monitor renal function and adjust use if necessary. - Existing liver disease: use under specialist supervision. - Potential drug interactions: review concomitant medications. - Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Major Interactions (Avoid): - Bile acid sequestrants: may significantly reduce cholic acid absorption. - Cyclosporine: increased risk of hepatotoxicity. - Warfarin: possible alteration of anticoagulant effect.

Moderate Interactions (Monitor Closely): - Oral contraceptives: may affect hormone levels. - Statins: monitor liver enzymes during combined therapy.