Orotre (Colecalciferol, Calcium Carbonate)

Colecalciferol, the active ingredient in Orotre, is a vitamin D3 supplement presented as an oral tablet containing calcium carbonate for combined supplementation. It helps correct vitamin D deficiency and supports calcium homeostasis in individuals at risk of low bone mineral density. The formulation is intended for oral use in adults and children as directed by a healthcare professional.

GNH USA supplies Orotre as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Orotre, containing colecalciferol and calcium carbonate, is used to address disorders of vitamin D and calcium metabolism. - Vitamin D deficiency: restores normal serum 25‑hydroxyvitamin D levels. - Calcium deficiency: provides elemental calcium to support bone health. - Osteoporosis prevention: assists in maintaining bone mineral density in at‑risk populations. - Hypocalcemia: helps raise low blood calcium concentrations.

Common Side Effects: - Nausea: mild stomach upset may occur. - Constipation: occasional difficulty passing stool. - Abdominal discomfort: mild cramps or pain. - Headache: transient head pain. - Dry mouth: sensation of oral dryness. - Flatulence: increased gas production.

Serious or Rare Side Effects: - Hypercalcemia: elevated blood calcium levels causing weakness or cardiac arrhythmia. - Kidney stones: formation of calcium‑based calculi in the urinary tract. - Allergic reaction: rash, itching, swelling, or breathing difficulty. - Hypervitaminosis D: toxicity from excessive vitamin D leading to calcification of soft tissues. - Hypercalciuria: excessive urinary calcium excretion increasing renal risk.

Before using Orotre, consider the following precautions: - Pregnancy and lactation: consult a healthcare provider before use. - Renal impairment: monitor calcium levels and adjust intake as needed. - Existing hypercalcemia: avoid use if blood calcium is already elevated. - Drug interactions: review all concurrent medications with a professional. - Age considerations: dosage may differ for children and the elderly. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture and light.

Orotre may interact with several medications. Review the following: Major Interactions (Avoid): - Thiazide diuretics: can increase risk of hypercalcemia. - High-dose vitamin A supplements: may potentiate vitamin D toxicity. - Lithium therapy: may affect calcium metabolism. Moderate Interactions (Monitor Closely): - Oral bisphosphonates: concurrent use may alter calcium balance. - Corticosteroids: may reduce calcium absorption, requiring monitoring. - Antacids containing aluminum or magnesium: can decrease calcium carbonate absorption.