GNH USA

Europe — EMA

Oriens (Mizolastine)

GNH USA supplies Oriens (Mizolastine), an antihistamine for allergic rhinitis and chronic urticaria, providing symptomatic relief.

Mizolastine

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What is Mizolastine?

Mizolastine, the active ingredient in Oriens, is a antihistamine presented as a tablet for oral use. It relieves symptoms of allergic rhinitis and chronic urticaria in adults and children. GNH USA supplies Oriens as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Mizolastine used for?

Mizolastine acts on histamine H1 receptors to alleviate allergic conditions. - Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery discharge. - Chronic idiopathic urticaria: diminishes the frequency and severity of hives and associated itching. - Seasonal allergic conjunctivitis: alleviates eye itching, redness and tearing.

What are the side effects of Mizolastine?

Mizolastine may cause a range of adverse reactions.

Common Side Effects: - Drowsiness: mild to moderate sedation. - Headache: transient cranial discomfort. - Dry mouth: reduced salivation. - Fatigue: general tiredness. - Nausea: occasional stomach upset. - Dizziness: brief episodes of light‑headedness.

Serious or Rare Side Effects: - Cardiac arrhythmia: irregular heart rhythm. - Severe allergic reaction: anaphylaxis or angioedema. - Hepatic dysfunction: elevated liver enzymes. - Leukopenia: reduced white blood cell count. - Seizures: rare convulsive episodes. - Psychosis: rare mental status changes.

What precautions apply to Mizolastine?

Mizolastine should be used with attention to safety considerations. - Assess liver function: monitor hepatic enzymes before and during therapy. - Avoid operating machinery: sedation may impair alertness. - Use caution in renal impairment: dose adjustment may be required. - Limit concurrent CNS depressants: increased sedation risk. - Pregnancy and lactation: consult a physician before use. - Store at ambient temperature: keep in original container, protect from moisture.

What does Mizolastine interact with?

Mizolastine can interact with several drug classes.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors: may raise mizolastine plasma levels. - Alcohol: additive central nervous system depression. - Other antihistamines: risk of excessive sedation.

Moderate Interactions (Monitor Closely):\n- CNS depressants (e.g., benzodiazepines): monitor sedation. - Anticholinergic agents: may intensify dry‑mouth effect. - Theophylline: possible reduction in antihistamine efficacy.

Frequently asked questions

What conditions is Oriens (Mizolastine) used for?+
Oriens, containing mizolastine, is indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria, helping to reduce nasal congestion, sneezing, itching, and the occurrence of hives.
How does mizolastine work to relieve allergy symptoms?+
Mizolastine works by selectively blocking peripheral H1 histamine receptors, preventing histamine‑mediated vasodilation and increased vascular permeability, and by stabilising mast cells to limit the release of inflammatory mediators.
What is the usual dose of Oriens?+
The appropriate dose of Oriens is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of symptoms, and clinical response.
Is mizolastine safe during pregnancy or breastfeeding?+
Safety of mizolastine in pregnancy or lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using Oriens.
How do I order Oriens from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does mizolastine compare with other antihistamines?+
Mizolastine is a second‑generation H1 antagonist offering effective allergy relief with a lower incidence of sedation compared with first‑generation antihistamines, while still providing a rapid onset of action.
What are the recommended storage conditions for Oriens?+
Oriens should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light, ensuring the tablet’s stability throughout its shelf life.
How is Oriens administered?+
Oriens is supplied as an oral tablet and is taken by mouth with or without food, as directed by the prescribing clinician.
What are the most serious risks associated with mizolastine?+
Serious risks, though rare, include cardiac arrhythmia, severe allergic reactions such as anaphylaxis, hepatic dysfunction, leukopenia, seizures, and psychotic episodes. Patients should seek immediate medical attention if any of these occur.
Who should not use mizolastine?+
Mizolastine is contraindicated in individuals with known hypersensitivity to mizolastine or any of its excipients, and should be used with caution in patients with severe hepatic impairment, uncontrolled cardiac disease, or a history of severe allergic reactions.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Mizolastine
Route
Oral Use
Manufacturer
Galenica Sa
Origin
EU

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