Oriduo (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine hydrochloride and fluticasone propionate, the active ingredients in Oriduo, are an antihistamine/corticosteroid combination presented as a nasal spray for nasal administration. It treats seasonal and perennial allergic rhinitis, relieving nasal congestion, sneezing, itching and rhinorrhea in adults and children.

GNH USA supplies Oriduo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality manufacturing and regulatory compliance across global markets.

Oriduo acts on the allergic rhinitis pathway to control nasal inflammation and histamine‑mediated symptoms.

- Seasonal allergic rhinitis: reduces nasal congestion, sneezing, itching and runny nose. - Perennial allergic rhinitis: provides sustained relief of nasal symptoms throughout the year. - Allergic rhinitis overall: improves nasal airflow and quality of life by controlling inflammation.

Oriduo may cause local and systemic adverse reactions, which are categorized by frequency.

Common Side Effects: - Nasal irritation or burning sensation. - Headache. - Bitter taste in the throat. - Mild nosebleeds.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis). - Nasal septum perforation. - Vision changes or cataract formation with prolonged use.

Before using Oriduo, consider the following precautions to ensure safe and effective therapy.

- Pregnancy: consult a healthcare professional; safety data are limited. - Breastfeeding: discuss potential risks with a physician. - Age restrictions: not recommended for children under two years of age. - Active nasal infection: avoid use until infection resolves. - Concomitant nasal sprays: do not use multiple nasal sprays simultaneously to reduce irritation. - Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Oriduo can interact with other medicines; recognize major and moderate interactions to manage risk.

Major Interactions (Avoid): - Systemic corticosteroids: may increase systemic glucocorticoid exposure. - Strong CYP3A4 inhibitors (e.g., ketoconazole): can raise fluticasone levels. - Other intranasal antihistamines: additive local irritation.

Moderate Interactions (Monitor Closely): - Antifungal azoles: may modestly increase fluticasone exposure. - Ritonavir or other protease inhibitors: potential increase in corticosteroid effect. - Nasal decongestants: may enhance local irritation when combined.