Europe — EMA
Orap Forte (Pimozide)
GNH USA supplies Orap Forte (Pimozide), a typical antipsychotic for schizophrenia and Tourette syndrome. Request a quote for global supply to global buyers.
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What is Pimozide?
Pimozide, the active ingredient in Orap Forte, is a typical antipsychotic presented as a tablet for oral use. It treats schizophrenia and Tourette syndrome in adults and adolescents. GNH USA supplies Orap Forte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Pimozide used for?
Pimozide is a dopamine‑blocking antipsychotic used in disorders where excess dopaminergic activity contributes to symptoms. - Schizophrenia: reduces psychotic symptoms such as delusions, hallucinations and thought disorder. - Tourette syndrome: decreases the frequency and severity of motor and vocal tics.
What are the side effects of Pimozide?
Pimozide may cause a range of adverse reactions that vary in frequency and severity.
Common Side Effects: - Sedation or drowsiness - Extrapyramidal symptoms such as rigidity or tremor - Dry mouth and constipation - Dizziness or light‑headedness
Serious or Rare Side Effects: - Neuroleptic malignant syndrome - Tardive dyskinesia - Agranulocytosis or severe neutropenia - Cardiac arrhythmias, including QT prolongation
What precautions apply to Pimozide?
Before initiating therapy, clinicians should consider several safety measures. - Cardiac monitoring: baseline ECG and periodic checks for QT prolongation. - Neurological assessment: watch for early signs of extrapyramidal reactions. - Hepatic function: adjust if significant liver impairment is present. - Discontinuation: taper gradually to avoid withdrawal or rebound symptoms. - Pregnancy and lactation: use only if benefits outweigh potential risks, as safety data are limited. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.
What does Pimozide interact with?
Pimozide can interact with other medicines, affecting its efficacy or safety.
Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole) – may increase pimozide levels. - QT‑prolonging agents (e.g., quinidine) – additive risk of cardiac arrhythmias. - MAO inhibitors – heightened risk of severe hypotension and serotonin syndrome.
Moderate Interactions (Monitor Closely): - Antihypertensive drugs – may enhance blood‑pressure lowering effects. - Alcohol or other CNS depressants – can increase sedation and dizziness.
