GNH USA

Europe — EMA

Opuviz (Aflibercept)

GNH USA supplies Opuviz (Aflibercept), a VEGF inhibitor for neovascular AMD, diabetic macular edema and retinal vein occlusion. Request a quote for supply.

Aflibercept

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1
Pack/s

What is Aflibercept?

Aflibercept, the active ingredient in Opuviz, is a VEGF inhibitor presented as an intravitreal solution for intravitreal use. It treats neovascular age‑related macular degeneration, diabetic macular edema and macular edema secondary to retinal vein occlusion in adult patients. GNH USA supplies Opuviz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Aflibercept used for?

Opuviz is an anti‑VEGF agent that targets ocular neovascular disease pathways. - Neovascular age‑related macular degeneration (nAMD): improves visual acuity and reduces retinal fluid accumulation. - Diabetic macular edema (DME): decreases macular swelling and stabilizes vision. - Macular edema secondary to retinal vein occlusion (RVO): reduces edema and helps maintain visual function.

What are the side effects of Aflibercept?

Common Side Effects: - Ocular pain: mild discomfort after injection. - Conjunctival hemorrhage: small bleed on the eye surface. - Increased intraocular pressure: transient rise that usually normalizes. - Transient blurred vision: temporary visual disturbance.

Serious or Rare Side Effects: - Endophthalmitis: severe intraocular infection requiring urgent care. - Retinal detachment: separation of retinal layers that can threaten vision. - Severe intraocular inflammation: marked inflammatory response needing treatment. - Arterial thromboembolic events: rare systemic vascular complications. - Systemic hypersensitivity: allergic reactions ranging from rash to anaphylaxis.

What precautions apply to Aflibercept?

Prior to administration, clinicians should evaluate ocular and systemic risk factors. - Patient selection: assess for active ocular infection before injection. - Intraocular pressure monitoring: check IOP after the procedure. - Systemic vascular risk: evaluate history of thromboembolic disease. - Pregnancy and lactation: use only if benefits outweigh risks; data are limited. - Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Aflibercept interact with?

Aflibercept may interact with other ocular or systemic therapies. Major Interactions (Avoid): - Concurrent intraocular surgery: may increase infection risk. - Systemic anti‑VEGF therapy: potential additive vascular effects. - Use with corticosteroid intravitreal implants: heightened intraocular pressure risk.

Moderate Interactions (Monitor Closely): - Anticoagulants: monitor for ocular hemorrhage. - Systemic chemotherapy agents: observe for wound‑healing complications. - Topical ocular NSAIDs: may affect inflammation control.

Frequently asked questions

What conditions is Opuviz used to treat?+
Opuviz is indicated for the treatment of neovascular age‑related macular degeneration, diabetic macular edema, and macular edema secondary to retinal vein occlusion. In each condition it helps reduce retinal fluid and improve or stabilize visual acuity.
How does aflibercept work in the eye?+
Aflibercept acts as a decoy receptor that binds VEGF‑A, VEGF‑B and placental growth factor with high affinity. By sequestering these ligands, it blocks activation of VEGF receptors on retinal endothelial cells, inhibiting abnormal blood‑vessel growth and vascular leakage.
What is the usual dose of Opuviz?+
The dosing regimen for Opuviz is determined by the prescribing ophthalmologist based on the specific indication and patient response. The prescriber decides the volume to be injected and the interval between injections.
Is Opuviz safe to use during pregnancy or breastfeeding?+
Safety data for aflibercept in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.
How do I order Opuviz from GNH USA?+
To place an order, submit an enquiry on the Opuviz product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.
How does Opuviz compare with other anti‑VEGF drugs?+
Opuviz (aflibercept) has a broader binding profile, targeting VEGF‑A, VEGF‑B and placental growth factor, whereas some alternatives bind only VEGF‑A. Clinical studies suggest comparable efficacy in improving vision, with dosing intervals that may differ based on the specific condition and physician preference.
What are the storage requirements for Opuviz?+
Opuviz should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep it in the original packaging until ready for use to maintain stability.
How is Opuviz administered?+
Opuviz is given as an intravitreal injection directly into the vitreous cavity of the eye. The procedure is performed by a qualified ophthalmologist in a sterile setting, using a fine‑gauge needle to deliver the prescribed volume.
What are the most serious risks associated with Opuviz?+
Serious adverse events include endophthalmitis (severe eye infection), retinal detachment, significant intraocular inflammation, and rare systemic arterial thromboembolic events. Patients should be monitored closely for signs of infection, vision changes, or systemic vascular symptoms.
Who should not receive Opuviz?+
Opuviz is contraindicated in patients with active ocular infection at the injection site and should be used with caution in individuals with recent intraocular surgery, uncontrolled systemic vascular disease, or known hypersensitivity to aflibercept or any component of the formulation.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Aflibercept
Route
Intravitreal Use
Manufacturer
Samsung Bioepis Nl B.V.
Origin
EU

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