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What is Macitentan?
Macitentan, the active ingredient in Opsumit, is an endothelin receptor antagonist presented as a tablet for oral use. It treats pulmonary arterial hypertension in adults. GNH USA supplies Opsumit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
GNH USA supplies Opsumit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
What is Macitentan used for?
Opsumit is an endothelin receptor antagonist used in the management of pulmonary arterial hypertension, a disease affecting the pulmonary vascular pathway.
- Pulmonary arterial hypertension (PAH): Improves exercise capacity and delays disease progression. - WHO Group 1 PAH: Reduces risk of clinical worsening. - Chronic thromboembolic pulmonary hypertension (CTEPH) after operable disease: Supports long‑term management.
What are the side effects of Macitentan?
Opsumit may cause a range of adverse reactions, most of which are mild to moderate in severity.
Common Side Effects: - Headache - Nasal congestion - Upper respiratory tract infection - Peripheral edema - Fatigue - Dizziness
Serious or Rare Side Effects: - Liver enzyme elevation - Anemia - Pulmonary edema - Severe hypotension - Drug‑induced hepatitis - Fatal hemorrhage
What precautions apply to Macitentan?
When prescribing Opsumit, clinicians should consider several safety aspects and patient‑specific factors.
- Pregnancy avoidance: Teratogenic risk; use effective contraception. - Liver function monitoring: Check enzymes before and during therapy. - Anemia monitoring: Periodic hemoglobin assessment recommended. - Drug interactions: Review concomitant medications for endothelin‑related effects. - Renal impairment: Use with caution in severe renal dysfunction. - Store at below 25°C: Keep in the original packaging, protect from moisture.
What does Macitentan interact with?
Opsumite may interact with several medications, requiring attention to the interaction’s clinical significance.
Major Interactions (Avoid): - Cytochrome P450 3A4 inhibitors (e.g., ketoconazole) – increase macrotin t t t t t t t t t t t t. - Strong CYP 3P t t t t t t t t t t.
Moderate t t t t t: - Rifampicin t t t t t t t t t t t. - Calcium‑channel t t t t t t t t t t t.
