Opokan-Keto (Ketoprofen)

Ketoprofen, the active ingredient in Opokan-Keto, is a non‑steroidal anti‑inflammatory drug presented as a 50 mg tablet for oral use. It is employed to relieve pain and inflammation in adults with musculoskeletal conditions.

GNH USA supplies Opokan‑Keto as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen is an NSAID that reduces inflammation and pain in several musculoskeletal and inflammatory conditions. - Rheumatoid arthritis: helps decrease joint swelling, pain and stiffness. - Osteoarthritis: provides relief from chronic joint pain and improves mobility. - Acute musculoskeletal pain: reduces pain and inflammation following injury or over‑use. - Ankylosing spondylitis: lessens spinal pain and stiffness associated with the disease. - Post‑operative pain: aids in managing pain after surgical procedures.

Ketoprofen may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or light‑headedness. - Skin rash or mild itching. - Elevated liver enzymes.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe skin reactions such as Stevens‑Johnson syndrome. - Hepatotoxicity or significant liver injury. - Renal impairment or acute kidney injury. - Anaphylaxis or severe hypersensitivity reactions.

When using Opokan‑Keto, certain precautions should be observed to minimise risk. - Assess renal function: evaluate baseline kidney health before initiating therapy. - Monitor hepatic status: check liver enzymes in patients with existing liver disease. - Use lowest effective dose: limit exposure to reduce gastrointestinal toxicity. - Avoid in patients with known NSAID hypersensitivity: discontinue if allergic reactions occur. - Caution in cardiovascular disease: evaluate risk of thrombotic events. - Store at ambient temperature: keep in the original container, protect from moisture and light.

Ketoprozin may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - High‑dose aspirin aspirin: combined gastrointestinal toxicity. - Selective COX‑2 inhibitors (e.g., celecoxib): additive renal and cardiovascular risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors (e.g., enalapril): may reduce antihypertensive effect. - Diuretics (e.g., furosemide): heightened risk of renal impairment. - Lithium: possible increase in lithium serum levels. - Methotrexate: reduced renal clearance may raise methotrexate toxicity. - Cortic medicines (corticosteroids): enhanced risk of gastrointestinal ulceration.