GNH USA

Europe — EMA

Ophel (Opipramol Hydrochloride)

GNH USA supplies Ophel (Opipramol Hydrochloride), a tricyclic antidepressant for anxiety, somatoform and depressive disorders. Request a quote for supply.

Opipramol Hydrochloride

Request sourcing

1
Pack/s

What is Opipramol Hydrochloride?

Opipramol Hydrochloride, the active ingredient in Ophel, is a tricyclic antidepressant presented as a tablet for oral use. It treats generalized anxiety disorder, somatoform disorders, and depressive disorders in adult patients.

GNH USA supplies Ophel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Opipramol Hydrochloride used for?

Opipramol Hydrochloride is employed in the management of anxiety‑related and depressive conditions.

- Generalized anxiety disorder: reduces anxiety symptoms and improves overall functioning. - Somatoform disorders: alleviates somatic symptom burden and associated distress. - Depressive disorders: improves mood and lessens depressive symptoms.

What are the side effects of Opipramol Hydrochloride?

Adverse reactions may occur with Ophel use.

Common Side Effects: - Drowsiness - Dry mouth - Constipation - Dizziness - Weight gain - Blurred vision

Serious or Rare Side Effects: - Cardiac arrhythmia or QT prolongation - Severe hypotension - Hepatic dysfunction - Blood dyscrasias such as agranulocytosis - Seizures - Suicidal ideation or behavior

What precautions apply to Opipramol Hydrochloride?

Before initiating therapy, consider the following safety measures.

- Pregnancy: safety not established; avoid unless clearly needed. - Breastfeeding: unknown; weigh potential risks against benefits. - Elderly patients: start with a low dose and monitor for excessive sedation. - Concomitant CNS depressants: may increase sedation and respiratory depression. - Discontinuation: avoid abrupt cessation to reduce withdrawal risk. - Store at ambient temperature: keep below 25°C, retain in original packaging, and protect from moisture.

What does Opipramol Hydrochloride interact with?

Ophel may interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid): - Monoamine oxidase inhibitors (MAOIs): risk of severe hypertension or serotonin syndrome. - CNS depressants (e.g., benzodiazepines, alcohol): enhanced sedation and respiratory depression. - Anticholinergic drugs: additive anticholinergic effects.

Moderate Interactions (Monitor Closely): - Serotonergic agents (SSRIs, SNRIs): potential for serotonin syndrome. - Antihistamines: increased drowsiness. - Cardiac drugs (e.g., quinidine): possible QT interval prolongation.

Frequently asked questions

What is Ophel used for?+
Ophel contains Opipramol Hydrochloride and is indicated for the treatment of generalized anxiety disorder, somatoform disorders, and depressive disorders. It helps reduce anxiety symptoms, lessen somatic complaints, and improve mood in adult patients as prescribed by a qualified healthcare professional.
How does Opipramol Hydrochloride work?+
Opipramol Hydrochloride works by activating sigma‑1 receptors while blocking histamine H1, muscarinic, and serotonergic receptors. This unique receptor profile modulates neuronal activity, providing anxiolytic and antidepressant effects through enhanced neuroprotective signaling and reduced central nervous system excitability.
What is the usual dose of Ophel?+
The dosage of Ophel is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. Physicians determine the appropriate strength and frequency, and patients should follow the specific instructions provided on their prescription label.
Is Ophel safe during pregnancy or breastfeeding?+
Safety data for Opipramol Hydrochloride in pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, so it should only be used when the potential benefit justifies any possible risk to the fetus or infant. Consultation with a healthcare professional is essential.
How do I order Ophel from GNH USA?+
To order Ophel, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then replies with pricing, availability, shipping details and any necessary import documentation.
How does Ophel compare with other anxiolytic drugs?+
Unlike benzodiazepines, Ophel does not act primarily on GABA receptors and therefore has a lower risk of dependence. Compared with selective serotonin reuptake inhibitors, Ophel’s mechanism involves sigma‑1 receptor agonism and broader receptor antagonism, offering a distinct therapeutic profile that may be preferable in certain anxiety or somatoform presentations.
How should Ophel be stored and handled?+
Ophel tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture and direct sunlight, and ensure they are out of reach of children. Do not store in a refrigerator or freezer.
How is Ophel administered?+
Ophel is taken orally as a tablet. Swallow the tablet whole with a glass of water, preferably with or after a meal to reduce gastrointestinal discomfort. Do not crush, chew, or split the tablet unless specifically instructed by a healthcare provider.
What are the most serious risks to watch for while taking Ophel?+
Serious adverse reactions, although rare, include cardiac arrhythmias or QT‑interval prolongation, severe hypotension, hepatic dysfunction, blood dyscrasias such as agranulocytosis, seizures, and emergence of suicidal thoughts or behaviors. Patients should seek immediate medical attention if any of these symptoms occur.
Who should not use Ophel?+
Ophel should be avoided in individuals with known hypersensitivity to Opipramol Hydrochloride or any tablet excipients, patients currently receiving monoamine oxidase inhibitors, those with severe hepatic impairment, and patients with a history of serious cardiac conduction disorders. A thorough medical review by a prescriber is required before initiating therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Opipramol Hydrochloride
Route
Oral Use
Manufacturer
Aenova Ip Gmbh
Origin
EU

Related products

Apropol

Apropol

Opipramol Hydrochloride

Polfarmex S.A.
EU
Insidon

Insidon

Opipramol Hydrochloride

Laboratoires Juvise Pharmaceuticals
EU
Insidon

Insidon

Opipramol Hydrochloride

Laboratoires Juvise Pharmaceuticals
EU
Opipram

Opipram

Opipramol Hydrochloride

Krewel Meuselbach Gmbh
EU