GNH USA

Europe — EMA

Ondansetron Kabi (Ondansetron Hydrochloride Dihydrate)

GNH USA supplies Ondansetron Kabi (Ondansetron), a 5‑HT3 receptor antagonist for chemotherapy, radiation and post‑operative nausea.

Ondansetron Hydrochloride Dihydrate

Request sourcing

1
Pack/s

What is Ondansetron Hydrochloride Dihydrate?

Ondansetron Hydrochloride Dihydrate, the active ingredient in Ondansetron Kabi, is a 5-HT3 receptor antagonist presented as a 4 mg/2 ml sterile injectable solution for intravenous use. It is employed to prevent nausea and vomiting associated with chemotherapy, radiation therapy, and surgery.

GNH USA supplies Ondansetron Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

What is Ondansetron Hydrochloride Dihydrate used for?

Ondansetron is a 5‑HT3 receptor antagonist used to prevent nausea and vomiting associated with chemotherapy, radiation therapy, and surgery.

- Chemotherapy‑induced nausea and vomiting: reduces incidence and severity of symptoms. - Radiation‑induced nausea and vomiting: helps control nausea during radiotherapy. - Post‑operative nausea and vomiting: prevents nausea after surgical procedures.

What are the side effects of Ondansetron Hydrochloride Dihydrate?

Common Side Effects: - Headache: mild to moderate intensity. - Constipation: reduced bowel movements. - Dizziness: transient light‑headedness. - Fatigue: feeling of tiredness. - Diarrhoea: loose stools. - Abdominal pain: mild discomfort.

Serious or Rare Side Effects: - QT interval prolongation: may lead to cardiac arrhythmia. - Severe allergic reactions: rash, swelling, anaphylaxis. - Serotonin syndrome: agitation, hyperthermia, neuromuscular abnormalities. - Cardiac arrhythmia: irregular heart rhythm. - Severe hypotension: marked drop in blood pressure.

What precautions apply to Ondansetron Hydrochloride Dihydrate?

Before initiating therapy, consider the following precautions: - Cardiac history: assess ECG in patients with known QT prolongation. - Hypersensitivity: avoid in individuals with documented allergy to ondansetron or its excipients. - Hepatic impairment: dose adjustment may be required in severe liver disease. - Concomitant QT‑prolonging drugs: monitor for additive cardiac effects. - Pregnancy and lactation: evaluate risk‑benefit ratio before use. - Store at room temperature: keep in original container, protect from moisture and light.

What does Ondansetron Hydrochloride Dihydrate interact with?

Ondansetron may interact with several medications; awareness of the interaction level is essential.

Major Interactions (Avoid): - Cisapride: increased risk of serious cardiac arrhythmia. - Aprepitant: additive QT‑prolongation potential. - Other QT‑prolonging agents (e.g., quinidine, haloperidol): may exacerbate cardiac rhythm disturbances.

Moderate Interactions (Monitor Closely): - Rifampin: may reduce ondansetron plasma concentrations. - Carbamazepine: may lower therapeutic effectiveness. - Serotonergic agents (e.g., SSRIs, SNRIs): monitor for signs of serotonin syndrome.

Frequently asked questions

What is Ondansetron Kabi used for?+
Ondansetron Kabi contains ondansetron, a 5‑HT3 receptor antagonist that is used to prevent and treat nausea and vomiting caused by chemotherapy, radiation therapy, and surgical procedures.
How does ondansetron work?+
Ondansetron works by selectively blocking serotonin (5‑HT3) receptors in the gastrointestinal tract and the brain’s chemoreceptor trigger zone, thereby interrupting the signaling pathway that initiates the vomiting reflex.
What is the usual dose of Ondansetron Kabi?+
The specific dose and dosing schedule of Ondansetron Kabi are determined by the prescribing clinician based on the patient’s condition, treatment protocol, and individual factors. No standard dose is provided here.
Is Ondansetron Kabi safe during pregnancy or breastfeeding?+
Safety in pregnancy and lactation should be evaluated by the healthcare provider. Ondansetron may be used when the potential benefit justifies any potential risk to the fetus or infant, but a risk‑benefit assessment is essential.
How do I order Ondansetron Kabi from GNH USA?+
To order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
How does Ondansetron Kabi compare with other antiemetics?+
Ondansetron belongs to the 5‑HT3 antagonist class, offering rapid and effective control of nausea and vomiting with a favorable safety profile compared with older agents such as metoclopramide, which can cause extrapyramidal effects. Its targeted receptor blockade provides more specific antiemetic action.
What are the storage requirements for Ondansetron Kabi?+
Store Ondansetron Kabi at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and light, and avoid exposure to extreme temperatures.
How is Ondansetron Kabi administered?+
Ondansetron Kabi is supplied as a sterile injectable solution for intravenous (IV) administration. It is typically given as a slow IV push or infusion, according to the prescribing clinician’s instructions.
What are the most serious risks associated with Ondansetron Kabi?+
Serious risks include QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, and serotonin syndrome when combined with other serotonergic drugs. Patients should be monitored for these events, especially if risk factors are present.
Who should not use Ondansetron Kabi?+
Ondansetron Kabi should be avoided in individuals with known hypersensitivity to ondansetron or any of its excipients, and in patients with congenital long QT syndrome or a history of significant cardiac arrhythmias unless closely monitored.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Ondansetron Hydrochloride Dihydrate
Route
Intravenous Use
Manufacturer
Fresenius Kabi Nederland B.V.
Origin
EU

Related products

Cellondan

Cellondan

Ondansetron Hydrochloride Dihydrate

Stadapharm Gmbh
EU
Cellondan

Cellondan

Ondansetron Hydrochloride Dihydrate

Stadapharm Gmbh
EU
Emeset

Emeset

Ondansetron Hydrochloride Dihydrate

Amring Farma Srl
EU
Emetron

Emetron

Ondansetron Hydrochloride Dihydrate

Gedeon Richter Plc.
EU