Europe — EMA

Ondansetron Aurobindo

Ondansetron, the active ingredient in Ondansetron Aurobindo, is a 5-HT3 receptor antagonist presented as a strength/form for oral use.

Ondansetron

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What is Ondansetron?

Ondansetron, the active ingredient in Ondansetron Aurobindo, is a 5-HT3 receptor antagonist presented as a strength/form for oral use. It treats nausea and vomiting associated with chemotherapy, radiation therapy, and surgery in adult and pediatric patients.

GNH USA supplies Ondansetron Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Ondansetron used for?

Ondansetron is a selective 5‑HT3 receptor antagonist used in the management of nausea and vomiting across several clinical pathways. - Chemotherapy‑induced nausea and vomiting: Reduces the frequency and severity of acute and delayed episodes. - Radiation‑induced nausea and vomiting: Helps control nausea during and after radiotherapy. - Post‑operative nausea and vomiting: Decreases the incidence of nausea and vomiting after surgical procedures.

What are the side effects of Ondansetron?

Side effects are generally mild but can vary in frequency and severity.

Common Side Effects: - Headache: mild to moderate intensity. - Constipation: reduced bowel movements. - Diarrhoea: loose stools. - Fatigue: feeling of tiredness. - Dizziness: light‑headed sensation.

Serious or Rare Side Effects: - QT interval prolongation: cardiac rhythm changes detectable on ECG. - Severe allergic reaction: rash, itching, swelling, or difficulty breathing. - Serotonin syndrome: agitation, hyperreflexia, tremor when combined with serotonergic agents. - Hepatic dysfunction: elevated liver enzymes. - Anaphylaxis: rapid onset of airway compromise and hypotension.

What precautions apply to Ondansetron?

Before prescribing Ondansetron, clinicians should evaluate patient‑specific factors and monitor for adverse events. - Cardiac risk assessment: avoid in patients with known QT prolongation or arrhythmias. - Electrolyte balance: correct hypokalaemia, hypomagnesemia, or hypocalcaemia before use. - Concomitant serotonergic drugs: assess for potential serotonin syndrome. - Liver impairment: consider dose adjustment or increased monitoring. - Pregnancy and lactation: weigh benefits against potential risks. - Store at below 25°C: keep in the original packaging, protect from moisture and light.

What does Ondansetron interact with?

Ondansetron may interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Apomatinib ( ). - Apomatinib - .

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Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

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