Olsar Plus (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan medoxomil, the active ingredient in Olsar Plus, is an angiotensin II receptor blocker presented as a tablet for oral use. It treats hypertension in adult patients. GNH USA supplies Olsar Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH USA supplies Olsar Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Olsar Plus combines the ARB olmesartan medoxomil with the diuretic hydrochlorothiazide, acting on the renin‑angiotensin‑aldosterone system to lower blood pressure.

- Hypertension: helps reduce systolic and diastolic blood‑pressure readings. - Heart failure with reduced ejection fraction: supports fluid removal and blood‑pressure control. - Diabetic nephropathy in patients with hypertension and proteinuria: slows renal function decline by lowering intravascular pressure. - Chronic vascular risk management for patients at high cardiovascular risk including stroke and myocardial infarction risk. - Target to achieve blood‑pressure goals as recommended by clinical guidelines for hypertensive patients with comor ‑ com ‑ ​  

Side effects may arise from either component of Olsar Plus.

Common Side Effects: - Dizziness. - Headache. - Fatigue. - Increased urination. - Electrolyte disturbances (e.g., low potassium). - Mild gastrointestinal discomfort.

Serious or Rare Side Effects: - Severe hypotension. - Acute kidney injury. - Hyperkalemia. - Angio‑ema. - Liver enzyme elevation. - Blood‑cell abnormalities (e.g., neutropenia).

When prescribing Olsar Plus, clinicians should consider several safety aspects.

- Renal impairment: adjust dose or monitor function regularly. - Hepatic impairment: use with caution; monitor liver tests. - Electrolyte balance: check potassium and sodium levels periodically. - Pregnancy: avoid use, especially in the second and third trimesters. - Concomitant NSAIDs: increase risk of renal dysfunction. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Olsar Plus may interact with several medicines that affect blood pressure, electrolytes, or renal function.

Major Interactions (Avoid): - Potassium‑rich supplements or potassium‑sparing diuretics: risk of hyper‑kalaemia. - Aliskiren (in diabetic patients): heightened risk of renal impairment. - ACE inhibitors or other ARBs: additive hypotensive effect.

Moderate Interaction Monitor Closely: - Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt antihypertensive response and affect kidney function. - Lithium: increased lithium levels, risk of toxicity. - Antidiabetic drugs: enhanced glucose‑lowering effect, may need dose adjustment.