Europe — EMA
Olmesartan Medoxomil/Amlodipine Krka (Olmesartan Medoxomil, Amlodipine)
GNH USA supplies Olmesartan Medoxomil/Amlodipine (Olmesartan medoxomil and amlodipine), an ARB and calcium channel blocker for hypertension. Request a quote.
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What is Olmesartan Medoxomil, Amlodipine?
Olmesartan medoxomil and amlodipine, the active ingredient in Olmesartan Medoxomil/Amlodipine Krka, is an Angiotensin II receptor blocker and calcium channel blocker presented as a tablet for oral use. It treats hypertension in adult patients, helping to lower systolic and diastolic blood pressure and reduce cardiovascular risk.
GNH USA supplies Olmesartan Medoxomil/Amlodipine Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Olmesartan Medoxomil, Amlodipine used for?
Olmesartan Medoxomil/Amlodipine is used in the management of high‑blood‑pressure disorders, acting on the renin‑angiotensin system and vascular smooth‑muscle tone. - Hypertension: lowers systolic and diastolic blood pressure in patients with essential hypertension. - Isolated systolic hypertension: provides effective control of elevated systolic pressure in older adults. - Diastolic hypertension: reduces diastolic pressure when it is the predominant abnormality.
What are the side effects of Olmesartan Medoxomil, Amlodipine?
Common Side Effects: - Dizziness: sensation of light‑headedness, especially after standing. - Headache: mild to moderate pain often occurring early in therapy. - Peripheral edema: swelling of ankles or feet due to fluid accumulation. - Flushing: transient warmth and reddening of the skin. - Fatigue: general feeling of tiredness. - Nausea: mild stomach upset.
Serious or Rare Side Effects: - Angioedema: rapid swelling of face, lips, tongue, or throat. - Severe hypotension: dangerously low blood pressure causing fainting. - Hepatic dysfunction: abnormal liver enzyme elevations. - Myocardial infarction: rare occurrence of heart attack. - Arrhythmia: irregular heart rhythm. - Allergic reactions: rash, itching, or severe skin reactions.
What precautions apply to Olmesartan Medoxomil, Amlodipine?
Before initiating therapy, clinicians should consider patient‑specific factors and monitor for adverse events. - Blood pressure monitoring: regularly assess to avoid excessive hypotension. - Renal impairment: adjust dose or monitor renal function closely. - Hepatic disease: use with caution in patients with severe liver dysfunction. - Pregnancy: not recommended; safety in pregnancy is unknown. - Electrolyte balance: monitor potassium levels when used with potassium‑sparing agents. - Store below 25°C: keep in the original pack, protect from moisture and direct sunlight.
What does Olmesartan Medoxomil, Amlodipine interact with?
Olmesartan Medoxomil/Amlodipine may interact with several drug classes, requiring careful management. Major Interactions (Avoid): - Aliskiren (in diabetic patients): increased risk of renal impairment. - Concurrent ARBs or ACE inhibitors: additive blood‑pressure lowering, risk of hyperkalemia. - Potassium‑sparing diuretics: may cause dangerous hyperkalemia. - Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): elevate amlodipine levels. - Grapefruit juice: can increase amlodipine exposure. Moderate Interactions (Monitor Closely): - NSAIDs: may blunt antihypertensive effect. - Lithium: increased lithium levels, risk of toxicity. - Rifampin: may reduce amlodipine concentrations. - Beta‑blockers: additive hypotensive effect, monitor heart rate. - Diuretics: may enhance electrolyte disturbances, watch potassium and sodium levels.
