Europe — EMA
Olmesartan Medoxomil/Amlodipine Accord Healthcare Ireland (Olmesartan Medoxomil, Amlodipine)
GNH USA supplies Olmesartan Medoxomil/Amlodipine (Olmesartan), a angiotensin II receptor blocker for hypertension. Request a quote for global supply.
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What is Olmesartan Medoxomil, Amlodipine?
Olmesartan medoxomil, the active ingredient in Olmesartan Medoxomil/Amlodipine Accord Healthcare Ireland, is a angiotensin II receptor blocker presented as a combination tablet for oral use. It treats hypertension, often in combination with other antihypertensive agents, and is suitable for adults. GNH USA supplies Olmesartan Medoxomil/Amlodipine Accord Healthcare Ireland as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
GNH USA supplies Olmesartan Medoxomil/Amlodipine Accord Healthcare Ireland as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
What is Olmesartan Medoxomil, Amlodipine used for?
Olmesartan medoxomil and amlodipine is used in the management of cardiovascular conditions that involve elevated blood pressure.
- Hypertension: improves blood pressure control when monotherapy is insufficient. - Chronic kidney disease with hypertension: slows progression of renal impairment. - Heart failure with preserved ejection fraction: assists in afterload reduction and symptom management. - Post‑myocardial infarction hypertension: helps maintain target blood pressure to reduce recurrent events. - High‑risk cardiovascular patients: contributes to overall cardiovascular risk reduction when combined with lifestyle measures.
What are the side effects of Olmesartan Medoxomil, Amlodipine?
Common Side Effects: - Peripheral edema: mild swelling of the ankles or feet. - Headache: transient, often resolves with continued therapy. - Dizziness: especially upon standing quickly. - Flushing: warm sensation, typically short‑lived. - Fatigue: general tiredness without other cause. - Palpitations: awareness of heartbeat, usually benign.
Serious or Rare Side Effects: - Angio‑edema: rapid swelling of face, lips, tongue, or throat. - Severe hypotension: marked drop in blood pressure causing fainting. - Hepatic dysfunction: elevated liver enzymes or jaundice. - Acute kidney injury: sudden reduction in renal function. - Myocardial infarction: rare occurrence of heart attack. - Blood dyscrasias: abnormal blood counts such as neutropenia.
What precautions apply to Olmesartan Medoxomil, Amlodipine?
Before initiating therapy, evaluate patient history and concomitant medications.
- Renal impairment: adjust dose and monitor kidney function regularly. - Hepatic disease: use with caution; monitor liver enzymes. - Electrolyte disturbances: check potassium and sodium levels. - Pregnancy: avoid use; drug is contraindicated in the second and third trimesters. - Elderly patients: start at lower dose and titrate slowly. - Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.
What does Olmesartan Medoxomil, Amlodipine interact with?
Olmesartan medoxomil/amlodipine may interact with several drug classes.
Major Interactions (Avoid): - Potassium‑rich supplements or potassium‑sparing diuretics: risk of hyper‑kalemia. - Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): increase amlodipine levels. - NSAIDs (high dose): may blunt antihypertensive effect and affect renal function.
Moderate Interactions (Monitor Closely): - Diuretics: may enhance hypotensive effect, requiring dose adjustment. - Lithium: increased lithium levels, monitor serum concentrations. - Antidiabetic agents: may require adjustment of glucose‑lowering therapy.
