Europe — EMA
Olmesartan E Amlodipina Aurobindo (Olmesartan Medoxomil, Amlodipine)
GNH USA supplies Olmesartan E Amlodipina Aurobindo (Olmesartan/amlodipine), a dual‑acting antihypertensive for hypertension and related cardiovascular
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What is Olmesartan Medoxomil, Amlodipine?
Olmesartan medoxil, the active ingredient in Olmesartan E Amlodipina Aurobindo, is an angiotensin II receptor blocker presented as a tablet for oral use. It treats hypertension, often in combination with a calcium‑channel blocker, and is intended for adult patients. GNH USA supplies Olmesartan E Amlodipina Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
GNH USA supplies Olmesartan E Amlodipina Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
What is Olmesartan Medoxomil, Amlodipine used for?
Olmesartan / amlodipine is used to manage high blood pressure by targeting the renin‑angiotensin system and vascular smooth‑muscle tone.
- Hypertension: lowers systolic and diastolic blood pressure to reduce cardiovascular risk. - Chronic kidney disease with hypertension: provides renal protection by controlling blood pressure. - Heart failure with reduced ejection fraction (as adjunct therapy): assists in afterload reduction when combined with standard heart‑failure regimens. - Post‑myocardial infarction hypertension: helps maintain target blood pressure after an acute coronary event. - Elderly patients with isolated systolic hypertension: offers effective blood‑pressure control with a favorable tolerability profile.
What are the side effects of Olmesartan Medoxomil, Amlodipine?
Common Side Effects: - Headache: mild to moderate intensity. - Peripheral edema: swelling of ankles or feet. - Dizziness or light‑headedness: especially after the first doses. - Flushing: transient warmth sensation. - Fatigue: general tiredness. - Palpitations: awareness of heartbeat.
Serious or Rare Side Effects: - Angio‑edema: rapid swelling of face, lips, tongue, or airway. - Severe hypotension: symptomatic low blood pressure. - Hepatic dysfunction: elevated liver enzymes or jaundice. - Acute kidney injury: sudden decline in renal function. - Myocardial infarction: rare occurrence of heart attack. - Blood dyscrasias: neutropenia or thrombocytopenia.
What precautions apply to Olmesartan Medoxomil, Amlodipine?
When using Olmesartan / amlodipine, consider the following precautions:
- Pregnancy: contraindicated; risk of fetal toxicity. - Breastfeeding: not recommended; potential excretion in milk. - Renal impairment: dose adjustment may be required; monitor kidney function. - Hepatic impairment: use with caution; monitor liver enzymes. - Electrolyte imbalance: watch for potassium abnormalities. - Drug‑induced hypotension: avoid abrupt posture changes. - Store at ambient temperature: keep below 25 °C, protect from moisture and light.
What does Olmesartan Medoxomil, Amlodipine interact with?
Olmesartan / amlodipine may interact with several medicines. Review the following groups:
Major Interactions (Avoid): - Dual renin‑angiotensin system blockade (e.g., ACE inhibitors, other ARBs): increased risk of hyperkalaemia and renal dysfunction. - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): elevated amlodipine levels.
Moderate Interactions (Monitor Closely): - Diuretics: additive blood‑pressure lowering effect, may cause hypotension. - NSAIDs: may blunt antihypertensive response and affect renal function. - Lithium: increased lithium levels, risk of toxicity. - Simvastatin: amlodipine raises simvastatin concentrations, risk of myopathy. - Alcohol: may enhance dizziness and hypotensive effects.
