Europe — EMA
Olmesartan/Amlodipine Krka (Olmesartan Medoxomil, Amlodipine)
GNH USA supplies Olmesartan/Amlodipine Krka (Olmes4 ... ), ... .... ... ... … … … … … … … … … … … … ...
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What is Olmesartan Medoxomil, Amlodipine?
Olmesartan medoxil, the active ingredient in Olmesartan/Amlodipine Krka, is an ARB presented as a strength/form for oral use. It treats hypertension, often in combination with other antihypertensive agents, and is suitable for adult patients. GNH USA supplies Olmesartan/Amlodipine Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
GNH USA supplies Olmesartan/Amlodipine Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Olmesartan Medoxomil, Amlodipine used for?
Olmesartan/Amlodipine combines a renin‑angiotensin system blocker with a calcium‑channel blocker to manage high blood pressure.
- Hypertension: improves blood pressure control when monotherapy is insufficient. - Hypertensive heart disease: reduces cardiac workload and risk of progression. - Chronic kidney disease with hypertension: slows renal function decline associated with high blood pressure.
What are the side effects of Olmesartan Medoxomil, Amlodipine?
Side effects may vary in frequency and severity.
Common Side Effects: - Dizziness - Peripheral edema - Headache - Flushing - Fatigue - Nausea
Serious or Rare Side Effects: - Angio‑edema - Severe hypotension - Hepatic dysfunction - Myocardial infarction - Arrhythmias - Acute kidney injury
What precautions apply to Olmesartan Medoxomil, Amlodipine?
When prescribing Olmesartan/Amlodide, clinicians should consider several safety aspects.
- Monitor blood pressure: ensure adequate control without excessive lowering. - Assess renal function: adjust use in patients with impaired kidneys. - Check electrolytes: watch for potassium abnormalities. - Review concomitant antihypertensives: avoid additive hypotensive effects. - Pregnancy: contraindicated in the second and third trimesters. - Store at below 25°C: keep in the original packaging and protect from moisture.
What does Olmesartan Medoxomil, Amlodipine interact with?
Olmesartan/Amlodipine may interact with several drug classes, requiring clinical awareness.
Major Interactions (Avoid): - Potassium‑rich supplements/diuretics: increase risk of hyper‑kalemia. - Strong CYP3A4 inhibitors (e.g., ketoconazole): raise amlodipine levels. - NSAIDs: may blunt antihypertensive response and affect renal function.
Moderate Interactions (Monitor Closely): - Other antihypertensives: risk of additive hypotension. - Lithium: monitor serum levels for toxicity. - Rifampin: may reduce amlodipine exposure.
