Olivin (Enalapril Maleate)

Enalapril, the active ingredient in Olivin, is an Angiotensin-Converting Enzyme (ACE) Inhibitor presented as a tablet for oral use. It is used to manage hypertension and certain cardiac conditions in adults.

GNH USA supplies Olivin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Enalapril is an ACE inhibitor that acts on the renin‑angiotensin system to lower blood pressure and protect the heart. - Hypertension: Helps reduce the risk of stroke and cardiovascular events by lowering blood pressure. - Heart failure: Improves symptoms and reduces hospital‑readmission rates in patients with reduced ejection fraction. - Diabetic nephropathy: Slows the progression of kidney damage in type 2 diabetes patients.

Adverse reactions to enalapril may vary in frequency and severity.

Common Side Effects: - Cough: dry, persistent cough reported by many patients. - Dizziness: especially when standing up quickly. - Headache: mild to moderate intensity. - Fatigue: general feeling of tiredness. - Hyperkalemia: elevated blood potassium levels. - Renal function changes: slight increase in serum creatinine.

Serious or Rare Side Effects: - Angio‑edema: swelling of lips, tongue, or airway requiring emergency care. - Severe hypotension: marked drop in blood pressure causing fainting. - Acute kidney injury: rapid decline in renal function. - Neutropenia or agranulocytosis: dangerously low white‑blood‑cell counts. - Hepatotoxicity: liver enzyme elevations or hepatitis. - Stevens‑Johnson syndrome: severe skin reaction.

When prescribing enalapril, clinicians should assess patient history and monitor key parameters. - Renal impairment: adjust dose and monitor creatinine and potassium. - Hyperkalemia risk: avoid concurrent potassium‑sparing diuretics or supplements. - Pregnancy: contraindicated in second and third trimesters due to fetal toxicity. - Elderly patients: start with lower dose and monitor for hypotension. - Drug‑induced cough: evaluate if persistent and affecting adherence. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Enalapril may interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Aliskiren: combined use can cause excessive hypotension and renal dysfunction. - Lithium: enalapril can increase lithium levels, raising toxicity risk. - NSAIDs: may blunt antihypertensive effect and worsen renal function.

Moderate Interactions (Monitor Closely): - Potassium‑rich foods or supplements: may exacerbate hyper‑kalaemia. - Diuretics (loop or thiazide): can enhance hypotensive effect, especially at therapy start. - Angiotensin II receptor blockers (ARBs): concurrent use increases risk of kidney injury and high potassium.