GNH USA

Europe — EMA

Olimel N12e

GNH USA supplies Olimel N12e (amino acid solution), a parenteral nutrition for patients requiring intravenous amino acid supplementation.

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin

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What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin, the active ingredient in Olimel N12e, is a parenteral nutrition (amino acid solution) presented as a solution for injection for intravenous use. It provides essential amino acids to patients who require total parenteral nutrition because oral or enteral feeding is not possible.

GNH USA supplies Olimel N12e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin used for?

Olimel N12e is used in parenteral nutrition to supply essential amino acids for patients who cannot receive enteral feeding.

- Parenteral nutrition: supports protein synthesis and nitrogen balance in patients receiving total parenteral nutrition. - Amino acid supplementation: restores essential amino acid levels in critically ill or postoperative patients. - Support of patients unable to receive enteral nutrition: provides necessary nutrients when gastrointestinal tract use is contraindicated.

What are the side effects of Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Adverse reactions may occur with any intravenous amino acid solution. Monitoring during infusion is recommended.

Common Side Effects: - Hyperglycemia: elevated blood glucose levels during infusion. - Electrolyte imbalance: changes in potassium, sodium or calcium concentrations. - Phlebitis: inflammation of the vein at the infusion site. - Mild nausea or vomiting. - Transient headache.

Serious or Rare Side Effects: - Anaphylactic reaction: severe allergic response requiring immediate medical attention. - Metabolic acidosis: significant drop in blood pH. - Severe hypotension: sudden low blood pressure. - Renal dysfunction: worsening kidney function in susceptible patients. - Thrombosis: clot formation at the catheter site.

What precautions apply to Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Careful assessment and monitoring are required when administering Olimel N12e.

- Monitor blood glucose: patients may develop hyperglycemia during infusion. - Assess renal function: adjust dosing in patients with impaired kidney clearance. - Check electrolyte levels: risk of imbalances, especially potassium and calcium. - Observe infusion site: watch for phlebitis, infiltration or thrombosis. - Use aseptic technique: prevent contamination of the intravenous line. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin interact with?

Olimel N12e may interact with other medications or solutions administered concurrently.

Major Interactions (Avoid): - Concurrent high‑dose insulin therapy: may cause severe hypoglycemia. - Incompatible calcium‑containing solutions: can precipitate and obstruct lines.

Moderate Interactions (Monitor Closely): - Loop diuretics: may increase electrolyte loss, requiring closer monitoring. - Corticosteroids: may enhance protein catabolism, affecting amino acid balance. - Renal replacement therapy: may alter amino acid clearance and necessitate dose adjustment.

Frequently asked questions

What is Olimel N12e used for?+
Olimel N12e is an intravenous amino acid solution used as part of total parenteral nutrition. It supplies essential and non‑essential amino acids to patients who cannot receive nutrition through the gastrointestinal tract, supporting protein synthesis, nitrogen balance and overall metabolic needs.
How does the amino acid mixture in Olimel N12e work?+
The mixture provides the building blocks required for protein synthesis and replenishes nitrogen stores. Delivered directly into the bloodstream, the amino acids become immediately available for tissue repair, immune function, gluconeogenesis and other metabolic pathways, bypassing the need for intestinal absorption.
What is the usual dose of Olimel N12e?+
The dose of Olimel N12e is individualized. The prescribing clinician determines the volume and rate of infusion based on the patient’s weight, metabolic requirements, renal and hepatic function, and overall nutritional plan.
Is Olimel N12e safe to use during pregnancy or breastfeeding?+
Safety data for Olimel N12e in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.
How do I order Olimel N12e from GNH USA?+
To order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.
How does Olimel N12e compare with other parenteral amino acid solutions?+
Olimel N12e offers a balanced profile of ten essential amino acids in a single sterile solution, matching the composition of many standard TPN amino acid mixes. Compared with multi‑component kits, it simplifies preparation but the clinical choice depends on individual patient needs, electrolyte content and compatibility with other infusates.
What are the storage and handling requirements for Olimel N12e?+
The product must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Before use, inspect the container for any signs of leakage or particulate matter and allow the solution to reach room temperature if required by the administration protocol.
How is Olimel N12e administered?+
Olimel N12e is administered intravenously, typically via a central venous catheter or a peripheral line using an infusion pump. The infusion rate is set by the prescribing clinician based on the patient’s nutritional prescription and monitored for tolerance and metabolic response.
What are the most serious risks associated with Olimel N12e?+
Serious risks include anaphylactic reactions, severe metabolic acidosis, significant electrolyte disturbances, and renal dysfunction in susceptible patients. Prompt recognition of these events and immediate medical intervention are essential to mitigate harm.
Who should not receive Olimel N12e?+
Patients with known hypersensitivity to any of the amino acids, those with uncontrolled metabolic disorders such as severe hepatic failure, or individuals for whom compatible intravenous solutions cannot be ensured should not receive Olimel N12e. Clinical judgment is required for each case.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Route
Intravenous Use
Manufacturer
Baxter Hellas
Origin
EU