GNH USA

Europe — EMA

Olimel N12e

GNH USA supplies Olimel N12e (Valine et al.), a nutritional amino acid blend for critical illness, post‑operative recovery and severe malnutrition.

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin

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What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin, the active ingredient in Olimel N12e, is a mixture of essential and non‑essential amino acids presented as a sterile powder for intravenous use. It supports metabolic functions and protein synthesis in patients requiring nutritional supplementation.

GNH USA supplies Olimel N12e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin used for?

Olimel N12e provides amino acid supplementation for conditions that increase protein catabolism or impair nutrient absorption. - Critical illness: helps maintain nitrogen balance and supports tissue repair. - Post‑operative recovery: aids in wound healing and muscle preservation. - Severe malnutrition: contributes to rebuilding lean body mass when oral intake is insufficient.

What are the side effects of Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Amino acid solutions are generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Mild nausea or vomiting - Transient headache - Slight increase in serum urea nitrogen - Mild infusion site erythema - Temporary rise in serum potassium - Mild metabolic alkalosis

Serious or Rare Side Effects: - Anaphylactic reaction - Severe hyperkalemia - Acute respiratory distress syndrome (ARDS) - Thrombophlebitis at infusion site - Sepsis related to contaminated product - Severe metabolic acidosis

What precautions apply to Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

When using Olimel N12e, clinicians should consider patient‑specific factors and follow standard infusion protocols. - Renal impairment: adjust infusion rate and monitor electrolytes. - Hepatic dysfunction: observe for altered ammonia levels. - Electrolyte imbalance: check serum potassium and calcium before administration. - Hyperglycaemia risk: monitor blood glucose in diabetic patients. - Allergic history: assess for prior reactions to amino acid preparations. - Store at ambient temperature: keep in original container, protect from moisture and light.

What does Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin interact with?

Olimel N12e may interact with other intravenous therapies and metabolic modulators.

Major Interactions (Avoid): - High‑dose potassium chloride: risk of severe hyper‑kalemia. - Sodium bicarbonate bolus: may cause rapid shifts in acid‑base balance. - Certain antifungal azoles: can alter amino acid metabolism.

Moderate Interactions (Monitor Closely): - Loop diuretics: enhance potassium loss, requiring electrolyte monitoring. - Insulin therapy: may potentiate hypoglycaemia when combined with dextrose‑containing solutions. - Parenteral lipid emulsions: compete for infusion line space, increasing risk of incompatibility.

Frequently asked questions

What is Olimel N12e used for?+
Olimel N12e is an intravenous amino acid formulation used to provide nutritional support in patients who are critically ill, recovering from surgery, or suffering from severe malnutrition where oral intake is inadequate.
How does the amino acid blend in Olimel N12e work?+
The blend supplies essential and non‑essential amino acids that serve as building blocks for protein synthesis, stimulate the mTOR signaling pathway and help maintain nitrogen balance, which supports tissue repair and metabolic stability in catabolic states.
What is the usual dose of Olimel N12e?+
Dosing is individualized; the prescribing clinician determines the amount and infusion rate based on the patient’s weight, metabolic needs, renal and hepatic function, and overall clinical condition.
Is Olimel N12e safe during pregnancy or breastfeeding?+
Safety data are limited. Use is generally reserved for pregnant or lactating patients only when the potential benefit outweighs any potential risk, and it should be prescribed by a specialist familiar with maternal‑fetal considerations.
How do I order Olimel N12e from GNH USA?+
Submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.
How does Olimel N12e compare with other amino acid products?+
Olimel N12e offers a broad spectrum of ten amino acids in a single sterile powder, providing a balanced profile for protein synthesis. Compared with single‑component preparations, it reduces the need for multiple infusions and simplifies formulation of total parenteral nutrition regimens.
What are the storage and handling requirements for Olimel N12e?+
Store the product at ambient temperature, below 25 °C, in its original sealed container. Protect it from moisture, direct sunlight and extreme temperature fluctuations to maintain stability.
How is Olimel N12e administered?+
The powder is reconstituted with a suitable sterile diluent and administered intravenously under aseptic conditions, typically via a controlled infusion pump according to the clinician‑determined rate.
What are the most serious risks associated with Olimel N12e?+
Serious adverse events can include anaphylactic reactions, severe hyper‑kalemia, acute respiratory distress syndrome and metabolic acidosis. Immediate medical attention is required if any of these occur.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Route
Intravenous Use
Manufacturer
Baxter, S.L.
Origin
EU