GNH USA

Europe — EMA

Olimel N12e

GNH USA supplies Olimel N12e (amino acid solution), a parenteral nutrition product for patients unable to receive enteral feeding.

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin

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What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serine, the active ingredients in Olimel N12e, is an amino acid solution presented as a solution for injection for intravenous use. It provides essential and non‑essential amino acids to support protein synthesis and nitrogen balance in patients requiring parenteral nutrition.

GNH USA supplies Olimel N12e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin used for?

Olimel N12e, an amino acid solution for parenteral nutrition, is used to support protein synthesis and nitrogen balance in several clinical situations.

- Parenteral nutrition for patients unable to receive enteral feeding: provides essential amino acids to meet nutritional needs. - Support of protein synthesis in catabolic states: helps maintain lean body mass during severe illness or trauma. - Pre‑ and post‑operative nutritional support: supplies amino acids to aid recovery after surgery.

What are the side effects of Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Adverse reactions may occur with intravenous amino acid solutions.

Common Side Effects: - Phlebitis at infusion site: redness, pain, or swelling. - Mild hyperglycemia: transient elevation of blood glucose. - Electrolyte disturbances (e.g., hypokalemia): changes in serum potassium. - Nausea: occasional feeling of queasiness. - Vomiting: occasional episodes during infusion.

Serious or Rare Side Effects: - Anaphylactic reaction: severe allergic response requiring immediate treatment. - Severe metabolic acidosis: significant drop in blood pH. - Hyperammonemia: elevated ammonia levels, especially in hepatic impairment. - Renal dysfunction: impaired kidney function in susceptible patients.

What precautions apply to Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

When using Olimel N12e, clinicians should consider several safety measures.

- Assess renal function: adjust dosage in patients with impaired renal clearance. - Monitor electrolytes: amino acid solutions can affect serum potassium, phosphate, and magnesium levels. - Check liver function: patients with hepatic dysfunction may develop hyperammonemia. - Observe for infusion reactions: monitor site for redness, swelling, or pain. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin interact with?

Olimel N12e may interact with other therapies administered concurrently.

Major Interactions (Avoid): - Concurrent high‑dose glucose solutions: may cause hyperglycemia. - Other parenteral nutrition components (lipid emulsions) mixed in the same line: risk of precipitation.

Moderate Interactions (Monitor Closely): - Renal toxic drugs (e.g., aminoglycosides): increased risk of nephrotoxicity. - Diuretics: may exacerbate electrolyte shifts. - Insulin therapy: may require dose adjustment due to glucose load from the solution.

Frequently asked questions

What is Olimel N12e used for?+
Olimel N12e is an intravenous amino acid solution used as part of parenteral nutrition. It supplies essential and non‑essential amino acids to patients who cannot receive enteral feeding, supports protein synthesis during catabolic states, and provides nutritional support before and after surgery.
How does the amino acid mixture in Olimel N12e work?+
The mixture delivers a balanced profile of essential and non‑essential amino acids directly into the bloodstream. Cells absorb these amino acids and incorporate them into proteins, helping to maintain nitrogen balance, promote tissue repair, and counteract muscle loss during illness or after operative procedures.
What is the usual dose of Olimel N12e?+
The dose of Olimel N12e is individualized. A qualified prescriber determines the volume and rate of infusion based on the patient’s weight, metabolic needs, renal and hepatic function, and overall clinical condition. No fixed regimen is provided in the product information.
Is Olimel N12e safe to use during pregnancy or breastfeeding?+
Safety data for Olimel N12e in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician in consultation with the patient.
How do I order Olimel N12e from GNH USA?+
To order Olimel N12e, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.
How does Olimel N12e compare with other amino acid solutions?+
Olimel N12e offers a comprehensive blend of ten amino acids in a ready‑to‑use sterile solution. Compared with other products such as TrophAmine or Aminoplas, it provides a similar amino acid profile but may differ in concentration, osmolarity, and packaging. Choice of product often depends on institutional protocols, compatibility with other nutrition components, and logistical considerations.
What are the storage and handling requirements for Olimel N12e?+
Olimel N12e must be stored refrigerated at 2‑8 °C. Keep the vials in the original packaging, protect them from light, and avoid freezing or shaking. If the product reaches room temperature, it should be used promptly and not be re‑refrigerated.
How is Olimel N12e administered?+
The solution is administered intravenously, typically via a peripheral or central venous catheter. It is infused as a continuous or intermittent infusion, with the rate adjusted according to the patient’s metabolic requirements and clinical response. Administration should be performed by trained healthcare personnel under aseptic conditions.
What are the most serious risks associated with Olimel N12e?+
Serious risks include anaphylactic reactions, severe metabolic acidosis, hyperammonemia (especially in patients with liver dysfunction), and renal impairment. Monitoring of vital signs, blood chemistry, and organ function is essential during therapy to detect and manage these events promptly.
Who should not receive Olimel N12e?+
Patients with known hypersensitivity to any of the amino acids in the formulation should avoid Olimel N12e. Caution is also advised for individuals with severe hepatic failure, uncontrolled hyperglycemia, or those receiving incompatible intravenous solutions in the same line without proper flushing.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Route
Intravenous Use
Manufacturer
Baxter Healthcare Srl
Origin
EU