GNH USA

Europe — EMA

Olimel N12e

GNH USA supplies Olimel N12e (Amino Acid Blend), a nutritional supplement for malnutrition, peri‑operative care and kidney disease.

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin

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What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serine, the active ingredient in Olimel N12e, is a mixture of essential and non‑essential amino acids presented as a powder for oral use. It supports metabolic functions and protein synthesis in patients requiring nutritional supplementation.

GNH USA supplies Olimel N12e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin used for?

Olimel N12e provides amino acid supplementation that supports protein metabolism in several clinical contexts. - Malnutrition: helps restore nitrogen balance and supports tissue repair. - Pre‑ and post‑operative care: contributes to wound healing and recovery of lean body mass. - Chronic kidney disease: assists in managing protein‑energy wasting when dietary intake is insufficient.

What are the side effects of Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Amino acid mixtures are generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild to moderate gastrointestinal discomfort. - Diarrhea: loose stools, often transient. - Abdominal cramping: intermittent stomach pain. - Metallic taste: temporary alteration in taste perception. - Headache: mild headache without other neurological signs.

Serious or Rare Side Effects: - Allergic reaction: rash, itching, swelling, or difficulty breathing. - Hyperammonemia: elevated blood ammonia levels, particularly in severe liver disease. - Metabolic acidosis: rare disturbance of acid‑base balance. - Hyperuricemia: increased uric acid levels, potentially precipitating gout. - Severe electrolyte imbalance: abnormal potassium or sodium levels.

What precautions apply to Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

When using Olimel N12e, consider the following precautions to ensure safe administration. - Renal impairment: adjust dosage based on renal function and monitor labs. - Hepatic dysfunction: assess risk of hyperammonemia and monitor liver enzymes. - Pregnancy and lactation: use only if clearly indicated. - Concomitant medications: review for potential amino‑acid interactions. - Storage: Store below 25°C: keep in the original pack, protect from moisture.

What does Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin interact with?

Amino acid formulations can interact with certain medicines, requiring attention from the prescribing clinician.

Major Interactions (Avoid): - L‑tryptophan supplements: may increase serotonin syndrome risk when combined with serotonergic agents. - High‑dose vitamin C: can enhance renal excretion of certain amino acids, reducing efficacy.

Moderate Interactions (Monitor Closely): - Anticonvulsants (e.g., valproate): may alter plasma levels of branched‑chain amino acids. - Diuretics: can affect electrolyte balance when combined with high amino‑acid loads. - Antibiotics (e.g., tetracycline): chelation may reduce absorption of some amino acids.

Frequently asked questions

What is Olimel N12e used for?+
Olimel N12e is an oral amino‑acid powder that provides essential and non‑essential amino acids to support protein synthesis, improve nitrogen balance and aid recovery in patients with malnutrition, peri‑operative needs or chronic kidney disease‑related protein‑energy wasting.
How does the amino‑acid blend in Olimel N12e work?+
The blend supplies the individual amino acids required for cellular protein synthesis and activates the mTOR signaling pathway, which promotes tissue growth and repair. Some components also serve as precursors for neurotransmitters and metabolic intermediates, helping maintain overall metabolic homeostasis.
What is the usual dose of Olimel N12e?+
The prescribed dose of Olimel N12e is determined by the treating clinician based on the patient’s nutritional status, underlying condition and renal or hepatic function. Dosing is individualized and should follow the healthcare professional’s recommendation.
Is Olimel N12e safe during pregnancy or breastfeeding?+
Olimel N12e may be used during pregnancy or lactation only when clearly indicated by a healthcare professional. The benefits must outweigh any potential risk, and clinicians should monitor maternal and fetal health closely.
How do I order Olimel N12e from GNH USA?+
To order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
How does Olimel N12e compare with other amino‑acid products?+
Olimel N12e offers a comprehensive blend of ten amino acids in a single powder, providing a broader spectrum of substrates for protein synthesis compared with single‑amino‑acid formulations. This may simplify dosing and improve metabolic efficiency in patients needing extensive nutritional support.
What are the storage and handling requirements for Olimel N12e?+
Store the powder below 25 °C in its original packaging, protecting it from moisture and direct sunlight. Keep the container tightly closed to maintain stability and prevent contamination.
How is Olimel N12e administered?+
Olimel N12e is supplied as a powder for oral use. The content is typically reconstituted with water or a suitable beverage and taken according to the prescribing clinician’s instructions, often divided into multiple daily doses.
What are the most serious risks associated with Olimel N12e?+
Serious risks include allergic reactions such as rash, itching or breathing difficulty, and metabolic complications like hyperammonemia or severe electrolyte disturbances, particularly in patients with liver or kidney impairment.
Who should not use Olimel N12e?+
Patients with known hypersensitivity to any of the listed amino acids, those with severe hepatic failure at risk of hyperammonemia, or individuals with uncontrolled metabolic disorders should avoid using Olimel N12e unless a physician determines it is essential.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Route
Intravenous Use
Manufacturer
Baxter Sa
Origin
EU