Europe — EMA
Olimel N12e
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What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin, the active ingredient in Olimel N12e, is a mixture of essential and non‑essential amino acids presented as a sterile powder for intravenous use. It supports metabolic functions and protein synthesis in patients requiring nutritional supplementation.
GNH USA supplies Olimel N12e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.
What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin used for?
Olimel N12e provides a comprehensive amino‑acid profile tailored for clinical nutrition support. It is used in the following contexts: - Post‑operative recovery: Helps maintain nitrogen balance and supports tissue repair. - Severe malnutrition: Supplies essential amino acids to restore protein stores. - Critical illness or trauma: Contributes to metabolic stability and immune function. - Long‑term parenteral nutrition: Provides a balanced amino‑acid solution for patients unable to use the gastrointestinal tract.
What are the side effects of Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?
Adverse reactions to Olimel N12e are generally related to its intravenous administration and the amino‑acid composition.
Common Side Effects: - Mild infusion‑site erythema - Transient nausea - Slight increase in serum urea - Temporary elevation of liver enzymes - Mild headache - Low‑grade fever
Serious or Rare Side Effects: - Anaphylactic or severe hypersensitivity reaction - Acute metabolic acidosis - Hyperammonemia - Severe electrolyte imbalance - Thromboembolic events - Renal dysfunction
What precautions apply to Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?
When using Olimel N12e, clinicians should observe the following precautions: - Assess renal function: Adjust dosing in patients with impaired clearance. - Monitor liver enzymes: Watch for signs of hepatic stress. - Check electrolyte status: Correct imbalances before infusion. - Observe for hypersensitivity: Discontinue if severe reaction occurs. - Use aseptic technique: Prevent contamination during preparation. - Store at ambient temperature: keep in original container, protect from moisture and direct light.
What does Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin interact with?
Olimel N12e may interact with other agents administered intravenously. Awareness of the following interactions helps maintain safety:
Major Interactions (Avoid): - Concurrent high‑dose potassium chloride: risk of hyperkalemia. - Large-volume dextrose solutions: may cause osmotic shifts.
Moderate Interactions (Monitor Closely): - Loop diuretics: may exacerbate electrolyte loss. - Anticoagulants anticoagulants: alter clotting parameters. - Other parenteral nutrition modules: risk of cumulative amino‑acid excess. - Acid‑base modifying agents: affect metabolic balance. - Certain antibiotics antibiotics: may precipitate in mixed solutions.