GNH USA

Europe — EMA

Olimel N12e

GNH USA supplies Olimel N12e (Essential Amino Acids), a parenteral nutrition solution for patients needing intravenous amino acid supplementation.

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin

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What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serine, the active ingredient in Olimel N12e, is a mixture of essential amino acids presented as a sterile solution for injection for intravenous use. It provides nutritional support for patients who cannot meet protein requirements by oral intake, such as those on parenteral nutrition. GNH USA supplies Olimel N12e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin used for?

Olimel N12e supplies essential amino acids for patients receiving parenteral nutrition.

Parenteral nutrition: supports protein synthesis and metabolic needs in patients unable to eat orally. Critical care: provides amino acid supplementation for critically ill patients. Post‑operative recovery: aids tissue repair in patients requiring intravenous nutritional support.

What are the side effects of Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Adverse reactions may occur with any intravenous amino acid solution.

Common Side Effects: - Infusion site reactions: erythema, pain, or swelling at the catheter site. - Mild electrolyte disturbances: transient hypernatremia or hypokalemia. - Metabolic alkalosis: due to bicarbonate load in the solution. - Hyperglycemia: especially in patients receiving concomitant dextrose. - Nausea or mild gastrointestinal discomfort.

Serious or Rare Side Effects: - Anaphylactic or severe hypersensitivity reactions. - Severe hyperammonemia in patients with hepatic impairment. - Acute renal dysfunction or worsening of pre‑existing kidney disease. - Catheter‑related sepsis secondary to contaminated infusion.

What precautions apply to Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Clinicians should observe several safety measures before and during administration.

Assess renal function: evaluate creatinine clearance prior to initiation. Monitor electrolytes: check serum sodium, potassium, and bicarbonate regularly. Check for hypersensitivity: review patient history of amino acid or protein allergies. Use aseptic technique: ensure sterile handling of the infusion set and solution. Adjust for hepatic impairment: consider reduced nitrogen load in patients with liver disease. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin interact with?

Potential drug interactions should be reviewed to avoid complications.

Major Interactions (Avoid): - Concurrent high‑dose potassium supplements: may precipitate hyperkalemia. - Co‑administration with other parenteral nutrition solutions containing overlapping amino acids: risk of excess nitrogen load. - Renal replacement therapy (dialysis): alters amino acid clearance and may require dose adjustment.

Moderate Interactions (Monitor Closely): - Loop or thiazide diuretics: monitor electrolyte balance closely. - Insulin therapy: watch for fluctuations in blood glucose levels. - Corticosteroids: may increase protein catabolism, requiring closer nutritional assessment. - Anticoagulants used in catheter lines: observe for bleeding at infusion sites.

Frequently asked questions

What is Olimel N12e used for?+
Olimel N12e is an intravenous solution that provides a balanced blend of essential amino acids. It is used to support patients who require parenteral nutrition, such as those who cannot eat or absorb nutrients through the gastrointestinal tract, including critically ill, postoperative, or long‑term hospitalized individuals.
How does the amino acid mixture in Olimel N12e work?+
The amino acids in Olimel N12e are directly delivered into the bloodstream, where they become available for protein synthesis, nitrogen balance, and energy metabolism. By replenishing essential amino acid pools, the solution helps maintain lean body mass, supports wound healing, and sustains immune function during periods of nutritional deprivation.
What is the usual dose of Olimel N12e?+
The dose of Olimel N12e is individualized by the prescribing clinician based on the patient’s weight, metabolic needs, renal and hepatic function, and overall nutritional plan. Healthcare professionals calculate the appropriate volume and rate of infusion to meet the patient’s specific amino acid requirements.
Is Olimel N12e safe to use during pregnancy or breastfeeding?+
Safety data for Olimel N12e in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.
How do I order Olimel N12e from GNH USA?+
To order Olimel N12e, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and necessary import documentation.
How does Olimel N12e compare with other parenteral amino acid products?+
Olimel N12e offers a comprehensive profile of ten essential amino acids in a single sterile solution, matching or exceeding the amino acid composition of many standard parenteral nutrition formulations. Its EU‑origin manufacturing and GDP compliance provide assurance of quality, while the specific blend may differ from competitor products that use alternative ratios or additional non‑essential amino acids.
What are the storage and handling requirements for Olimel N12e?+
Olimel N12e must be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. Before use, inspect the vial for particulate matter or discoloration and allow it to reach room temperature if required for infusion.
How is Olimel N12e administered?+
The product is administered intravenously as a sterile solution. It is typically infused through a dedicated catheter or central line, with the rate and volume determined by the prescribing clinician based on the patient’s nutritional prescription and clinical status.
What are the most serious risks associated with Olimel N12e?+
Serious risks include severe hypersensitivity reactions such as anaphylaxis, hyperammonemia in patients with liver dysfunction, and acute renal impairment in susceptible individuals. Monitoring for signs of allergic reaction, metabolic disturbances, and renal function is essential during therapy.
Who should not receive Olimel N12e?+
Olimel N12e should be avoided in patients with known hypersensitivity to any of its amino acid components, those with uncontrolled severe electrolyte imbalances, or individuals with acute renal or hepatic failure where the risk of nitrogen overload outweighs benefit. Clinical judgment is required for each case.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Route
Intravenous Use
Manufacturer
Baxter D.O.O.
Origin
EU