Europe — EMA
Olimel N12
GNH USA supplies Olimel N12 (Amino Acid Mix), a parenteral nutrition supplement for critical illness, post‑operative recovery and severe malnutrition.
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What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin, the active ingredient in Olimel N12, is a parenteral nutrition supplement presented as a nutritional formulation for intravenous use. It provides essential amino acids for patients requiring nutritional support, particularly in critical care and postoperative settings.
GNH USA supplies Olimel N12 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and transplant centres worldwide.
What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin used for?
Olimel N12 is used as a component of parenteral nutrition regimens to support patients with complex metabolic needs. - Critical illness: helps maintain nitrogen balance and supports protein synthesis. - Post‑operative recovery: provides essential amino acids to aid wound healing. - Severe malnutrition: supplies necessary building blocks when oral intake is insufficient. - Long‑term home parenteral nutrition: sustains nutritional status for patients unable to eat orally.
What are the side effects of Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?
Adverse reactions to Olimel N12 are generally related to its intravenous administration and amino‑acid composition.
Common Side Effects: - Mild fever or chills during infusion. - Transient increase in blood urea nitrogen. - Local irritation at the infusion site. - Mild electrolyte disturbances (e.g., potassium shifts). - Headache. - Nausea.
Serious or Rare Side Effects: - Anaphylactic or severe hypersensitivity reaction. - Metabolic acidosis. - Hyperammonemia. - Severe electrolyte imbalance (e.g., hyperkalemia, hypocalcemia). - Thrombophlebitis at the catheter site. - Renal dysfunction exacerbation.
What precautions apply to Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?
When prescribing Olimel N12, clinicians should consider patient‑specific factors and monitor relevant parameters. - Renal impairment: adjust infusion rate and monitor nitrogen waste. - Hepatic dysfunction: watch for signs of hyperammonemia. - Electrolyte disorders: check serum electrolytes before and during therapy. - Fluid overload risk: assess volume status, especially in cardiac patients. - Allergic history: verify no known hypersensitivity to amino‑acid solutions. - Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.
What does Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin interact with?
Olimel N12 may interact with other intravenous solutions or medications that affect nitrogen balance and electrolyte status.
Major Interactions (Avoid): - High‑dose potassium chloride admixtures: risk of hyperkalemia. - Acidic drug solutions (e.g., certain antibiotics): may precipitate amino acids.
Moderate Interactions (Monitor Closely): - Loop diuretics: can exacerbate electrolyte shifts. - Corticosteroids: may increase protein catabolism, altering amino‑acid requirements. - Other parenteral nutrition components: ensure compatible mixing ratios. - Anticoagulants: monitor clotting parameters if central line is used.