GNH USA

Europe — EMA

Olimel N12

GNH USA supplies Olimel N12 (amino acids), a amino acid solution for parenteral nutrition in patients unable to receive enteral feeding.

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin

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What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin, the active ingredient in Olimel N12, is an amino acid solution presented as a solution for injection for intravenous use. It provides essential amino acids for patients requiring parenteral nutrition, supporting protein synthesis and nitrogen balance.

GNH USA supplies Olimel N12 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and clinics worldwide.

What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin used for?

Olimel N12, an amino acid solution for parenteral nutrition, is used to support protein and nitrogen needs in clinical situations where enteral feeding is not possible. - Parenteral nutrition for patients unable to receive enteral feeding: provides essential amino acids to meet nutritional requirements. - Surgical, trauma, or critically ill patients: supports protein synthesis and nitrogen balance during increased metabolic demand. - Patients with severe malnutrition or catabolic states: helps restore lean body mass and improve clinical outcomes.

What are the side effects of Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Adverse reactions to Olimel N12 may vary in frequency and severity.

Common Side Effects: - Hyperglycemia: elevated blood glucose levels, especially in diabetic patients. - Electrolyte disturbances: changes in serum potassium, calcium, or phosphate. - Infusion site reactions: erythema, pain, or phlebitis at the catheter site. - Nausea or vomiting: mild gastrointestinal discomfort.

Serious or Rare Side Effects: - Metabolic acidosis: significant acid‑base imbalance requiring medical intervention. - Allergic reactions: anaphylaxis, urticaria, or severe skin rash. - Hyperosmolarity: fluid overload or pulmonary edema in susceptible patients.

What precautions apply to Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

When prescribing or handling Olimel N12, consider the following precautions to ensure patient safety. - Renal impairment: monitor renal function and adjust amino acid load as needed. - Hepatic dysfunction: assess liver enzymes and avoid excess nitrogen load. - Fluid balance: watch for signs of fluid overload, especially in cardiac patients. - Electrolyte monitoring: regularly check serum electrolytes during therapy. - Hyperglycemia risk: closely monitor blood glucose in diabetic or pre‑diabetic patients. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin interact with?

Olimel N12 may interact with certain medications or clinical conditions.

Major Interactions (Avoid): - High‑dose insulin therapy: may exacerbate hypoglycemia when combined with amino acid‑induced glucose shifts. - Loop diuretics: can worsen electrolyte disturbances when amino acid solution is administered concurrently.

Moderate Interactions (Monitor Closely): - Corticosteroids: may increase protein catabolism, requiring adjustment of amino acid dosing. - Parenteral lipid emulsions: co‑administration can affect osmolarity and fluid balance. - Anticoagulants (e.g., heparin): monitor coagulation parameters as amino acids may influence platelet function.

Frequently asked questions

What is Olimel N12 used for?+
Olimel N12 is an amino acid solution intended for parenteral nutrition. It is used when patients cannot receive enteral feeding, providing essential amino acids to support protein synthesis, nitrogen balance, and overall nutritional needs in surgical, trauma, or critically ill settings.
How does the amino acid mixture in Olimel N12 work?+
The mixture supplies a balanced profile of essential and non‑essential amino acids directly into the bloodstream. These amino acids act as building blocks for new proteins, replenish nitrogen stores, and support metabolic processes such as tissue repair and immune function, bypassing the gastrointestinal tract.
What is the usual dose of Olimel N12?+
The dose of Olimel N12 is individualized. A qualified prescriber determines the volume and rate of infusion based on the patient’s weight, clinical condition, and nutritional requirements, following established parenteral nutrition guidelines.
Is Olimel N12 safe to use during pregnancy or breastfeeding?+
Safety data for Olimel N12 in pregnancy and lactation are limited. It should be used only if clearly needed and after a risk‑benefit assessment by the treating physician. Consultation with a specialist is recommended before use in these populations.
How do I order Olimel N12 from GNH USA?+
To order Olimel N12, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.
How does Olimel N12 compare with other amino acid solutions?+
Olimel N12 offers a comprehensive blend of ten amino acids in a single sterile solution, similar to other parenteral amino acid products such as Aminoplasmal or TrophAmine. Differences may lie in the exact amino acid composition, osmolarity, and regulatory approvals, which can influence compatibility with specific nutrition regimens.
What are the storage and handling requirements for Olimel N12?+
Olimel N12 must be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the container. Before use, inspect for particulate matter or discoloration and allow the solution to reach room temperature if required by the administration protocol.
How is Olimel N12 administered?+
Olimel N12 is administered intravenously as an infusion. It is typically added to a compatible carrier solution and infused through a central or peripheral venous line at a rate prescribed by the clinician, ensuring aseptic technique and appropriate monitoring during the infusion.
What are the most serious risks associated with Olimel N12?+
Serious risks include metabolic acidosis, severe allergic reactions such as anaphylaxis, hyperosmolarity leading to fluid overload or pulmonary edema, and significant electrolyte disturbances. Prompt recognition and management of these events are essential, and patients should be closely monitored during therapy.
Who should not use Olimel N12?+
Olimel N12 should be avoided in patients with known hypersensitivity to any of its amino acid components, in those with uncontrolled severe renal or hepatic failure, and in individuals where fluid overload or severe electrolyte imbalance would pose a high risk. Clinical judgment is required for each case.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Route
Intravenous Use
Manufacturer
Baxter S.P.A.
Origin
EU