Olicard Retard (Isosorbide Mononitrate)

Isosorbide Mononitrate, the active ingredient in Olicard Retard, is a nitrate vasodilator presented as a prolonged‑release oral tablet for once‑daily use in adults with chronic stable angina. It helps to prevent chest pain episodes by improving coronary blood flow.

GNH USA supplies Olicard Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Isosorbide Mononitrate is used in the management of angina‑related conditions, acting on the coronary circulation to reduce myocardial oxygen demand. - Chronic stable angina: reduces frequency of angina attacks and improves exercise tolerance. - Variant (Prinzmetal) angina: prevents episodic coronary spasm and associated chest pain. - Post‑myocardial infarction prophylaxis: helps lower risk of recurrent angina episodes during recovery.

Adverse reactions may occur with any nitrate therapy.

Common Side Effects: - Headache: mild to moderate, often transient. - Flushing: warmth and redness of the skin, especially face. - Dizziness or light‑headedness, particularly on standing. - Nausea or upset stomach. - Palpitations: sensation of rapid or irregular heartbeat.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure causing fainting. - Methemoglobinemia: abnormal hemoglobin that impairs oxygen delivery. - Allergic reactions: rash, itching, swelling, or difficulty breathing. - Syncope: sudden loss of consciousness unrelated to posture.

Before initiating therapy, clinicians should evaluate cardiovascular status and concomitant medications. - Assess blood pressure: avoid use in patients with uncontrolled hypotension. - Review cardiac history: caution in recent myocardial infarction or severe heart failure. - Evaluate liver and renal function: dose may need adjustment in impairment. - Avoid concurrent use of phosphodiesterase‑5 inhibitors: risk of profound hypotension. - Counsel on orthostatic changes: rise slowly from sitting or lying positions. - Store at ambient temperature: keep below 25°C in the original container, protected from moisture.

Isosorbide mononitrate interacts with several drug classes; careful monitoring is advised.

Major Interactions (Avoid): - Sildenafil, tadalafil, vardenafil: combined vasodilatory effect can cause severe hypotension. - Other nitrates (e.g., nitroglycerin): additive blood‑pressure lowering effect.

Moderate Interactions (Monitor Closely): - Antihypertensives (ACE inhibitors, ARBs, beta‑blockers): may enhance blood‑pressure reduction. - Diuretics: increase risk of electrolyte imbalance and hypotension. - Alcohol: can potentiate vasodilatory response and dizziness.