Olfen Sr (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen Sr, is a non‑steroidal anti‑inflammatory drug presented as a 50 mg tablet for oral use. It treats pain and inflammation associated with musculoskeletal disorders in adults. GNH USA supplies Olfen Sr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac sodium is an NSAID that reduces inflammation and pain in several musculoskeletal conditions. - Osteoarthritis: alleviates joint pain and improves mobility. - Rheumatoid arthritis: decreases joint swelling and stiffness. - Ankylosing spondylitis: relieves spinal pain and reduces inflammation. - Acute musculoskeletal injury: provides short‑term pain relief and reduces swelling. - Post‑operative pain: helps manage pain following minor surgical procedures.

Diclofenac sodium may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness: transient episodes of light‑headedness. - Skin rash: mild erythema or itching. - Elevated liver enzymes: mild, asymptomatic increases.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Severe hepatic injury or hepatitis. - Renal impairment or acute kidney injury. - Cardiovascular events such as myocardial infarction or stroke. - Severe skin reactions like Stevens‑Johnson syndrome.

When using Diclofenac sodium, consider the following safety measures: - Assess renal function: monitor creatinine and electrolytes in patients with kidney disease. - Evaluate hepatic status: check liver enzymes before initiating therapy. - Review cardiovascular risk: avoid in patients with recent myocardial infarction or uncontrolled hypertension. - Use gastro‑protective agents: consider proton‑pump inhibitors for patients at high GI risk. - Avoid concurrent NSAIDs: limit additive gastrointestinal toxicity. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Diclofenac sodium can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency. - ACE inhibitors or ARBs: may reduce renal perfusion and impair kidney function.

Moderate Interactions (Monitor Closely): - Diuretics: potential for reduced antihypertensive effect and electrolyte imbalance. - Lithium: increased lithium levels, risk of toxicity. - Methotrexate: reduced clearance, risk of toxicity.